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http://dx.doi.org/10.1038/s41590-024-01791-3 | DOI Listing |
Heart
January 2025
Centre for Congenital Heart Diseases, University Medical Centre Groningen, Groningen, Netherlands
Biochemistry (Mosc)
November 2024
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485, Russia.
Dependence on psychoactive substances is a phenomenon that is based on the alterations of common molecular and cellular mechanisms, structures and neuronal networks underlying normal brain functioning and realizing stress response, reinforcement and aversion, learning and memory. As a result, aberrant neuroplasticity states associated with somatic changes are formed, which determine the pathogenesis and symptoms of dependence and at the same time can be considered as targets for the development of therapies for such addictions. An integrative scheme of stress and neuroplastic changes participation in the formation of the vicious circle of substance use disorders based on a holistic approach is presented.
View Article and Find Full Text PDFEpilepsy Curr
January 2024
Epilepsy Division, Department of Neurology, University of Virginia School of Medicine.
Cancer Cell
June 2024
Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA. Electronic address:
Checkpoint blockade immunotherapies, such as anti-programmed death-1 (PD-1), unleash anti-tumor CD8 T cell responses but may also induce immunosuppressive regulatory T cells (Tregs). In this issue of Cancer Cell, Geels et al. uncover that anti-PD-1 leads to Treg expansion via interleukin-2 (IL-2)-producing CD8 T cells.
View Article and Find Full Text PDFNat Rev Neurosci
August 2024
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
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