AI Article Synopsis
Article Abstract
The aim of this study was to investigate the antiglioma effect of Cecropia pachystachya Trécul (CEC) leaves extract against C6 and U87 glioblastoma (GB) cells and in a rat preclinical GB model. The CEC extract reduced in vitro cell viability and biomass. In vivo, the extract decreased the tumor volume approximately 62%, without inducing systemic toxicity. The deficit in locomotion and memory and an anxiolytic-like behaviors induced in the GB model were minimized by CEC. The extract decreased the levels of reactive oxygen species, nitrites and thiobarbituric acid reactive substances and increased the activity of antioxidant enzymes in platelets, sera and brains of GB animals. The activity of NTPDases, 5'-nucleotidase and adenosine deaminase (ADA) was evaluated in lymphocytes, platelets and serum. In platelets, ATP and AMP hydrolysis was reduced and hydrolysis of ADP and the activity of ADA were increased in the control, while in CEC-treated animals no alteration in the hydrolysis of ADP was detected. In serum, the reduction in ATP hydrolysis was reversed by CEC. In lymphocytes, the increase in the hydrolysis of ATP, ADP and in the activity of ADA observed in GB model was altered by CEC administration. The observed increase in IL-6 and decrease in IL-10 levels in the serum of GB animals was reversed by CEC. These results demonstrate that CEC extract is a potential complementary treatment to GB, decreasing the tumor size, while modulating aspects of redox and purinergic systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12035-024-04086-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Behavior of Silver Species in Soil: Ag Nanoparticles vs. Ionic Ag.
Molecules
November 2024
Institute of Environmental Engineering, Polish Academy of Sciences, 34 M Skłodowska-Curie St., 41-819 Zabrze, Poland.
Silver nanoparticles are one of the most commonly used forms of silver (Ag) in nanotechnology applications due to their antibacterial properties and electrical and thermal resistance. The increasing production and use of products containing nanoparticles has led to their release into and contamination of soil and water. This review summarizes the literature on the fate, behavior (adsorption/desorption, precipitation/oxidative dissolution, transformation), and transport/mobility of Ag forms in soils (Ag ions and Ag nanoparticles-AgNPs).
View Article and Find Full Text PDFClassification of speech arrests and speech impairments during awake craniotomy: a multi-databases analysis.
Int J Comput Assist Radiol Surg
December 2024
Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
Article Synopsis
- The paper discusses using a deep learning model to objectively assess speech functions during awake craniotomies, aiming to improve surgical outcomes by minimizing reliance on clinician observations.
- It involved analyzing 1883 audio clips from surgeries in Japan and France to train a Wav2Vec2-based model, which achieved an F1-score of 84.12% for Japanese data and 74.68% when tested across languages.
- While the initial results are promising, further evaluation and integration of noise reduction techniques are necessary to enhance the model's performance and accuracy.
[Spatial-temporal Distribution and Ecological Risk of Antibiotics in the Soils of a Typical Agricultural Watershed in the Three Gorges Reservoir Area].
Huan Jing Ke Xue
November 2024
Chongqing Key Laboratory of Agricultural Resources and Environment, College of Resources and Environment, Southwest University, Chongqing 400715, China.
In order to understand the spatial-temporal distribution and ecological risk of antibiotics in the soil of an agricultural watershed in the Three Gorges Reservoir area, the topsoil samples were collected at 26 sites in the Wangjiagou small watershed, Fuling District, Chongqing in spring, summer, autumn, and winter of 2022, and 21 antibiotics with five classes were determined using solid phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. The content levels and spatial-temporal distribution of antibiotics were analyzed, the correlations between antibiotic contents and soil physicochemical factors were discussed, and the potential ecological risk of antibiotics in the soil was evaluated using the risk quotient method. The results showed that the detection rates of 21 antibiotics were 0-100% with the range of ND-219.
View Article and Find Full Text PDFEvaluation of modified fire hawk optimizer for new modification in double diode solar cell model.
Sci Rep
December 2024
Faculty of Computers and Information, Minia University, Minia, Egypt.
The evaluation of photovoltaic (PV) model parameters has gained importance considering emerging new energy power systems. Because weather patterns are unpredictable, variations in PV output power are nonlinear and periodic. It is impractical to rely on a time series because traditional power forecast techniques are based on linearity.
View Article and Find Full Text PDFEffect of biodegradable microplastics and Cd co-pollution on Cd bioavailability and plastisphere in soil-plant system.
Chemosphere
December 2024
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, Shanghai Academy of Environmental Sciences, Shanghai 200233, China; School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address:
Biodegradable plastics (BPs) are regarded as ecomaterials and are emerging as a substitute for traditional non-degradable plastics. However, the information on the interaction between biodegradable microplastics (BMPs) and cadmium (Cd) in agricultural soil is still limited. Here, lettuce plants were cultured in BMPs (polylactic acid (PLA) MPs and poly(butylene-adipate-co-terephthalate) (PBAT) MPs) and Cd co-polluted soil for 35 days.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!