AI Article Synopsis

  • Most tumors result from genetic changes, but some are linked to viral infections like HPV, which can lead to specific skin conditions.
  • Epidermodysplasia verruciformis (EDV) is a rare HPV infection characterized by unique histological features and specific HPV subtypes.
  • The study discusses a particular type of EDV-related tumor found in two patients, highlighting consistent features and suggesting it could be a unique, reproducible form of skin tumor.

Article Abstract

Most tumors are caused by inherited or acquired genetic changes. However, a subset of tumors is driven by viral infection including Kaposi sarcoma, nasopharyngeal carcinoma, and others. Human papillomavirus (HPV) is an especially common cause of epithelial cancers and hyperplasias. Epidermodysplasia verruciformis (EDV) is a rare type of HPV infection with characteristic histopathologic features and a unique spectrum of HPV subtypes. We report here a distinctive form of EDV-associated eccrine neoplasia. Seven tumors from two patients were analyzed and show highly uniform features including multiple clustered clinical lesions, multifocal epidermal origin, eccrine differentiation with close association with the acrosyringium, an anastomosing growth pattern, and a bland monotonous poroid-to-basaloid cytomorphology. Clinical follow-up for one patient has been benign to date. These tumors show strong similarity to two previously reported cases, suggesting that this type of EDV-associated eccrine neoplasia may represent a rare but reproducible form of skin adnexal tumor with distinctive clinicopathologic features.

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Source
http://dx.doi.org/10.1007/s00428-024-03785-wDOI Listing

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