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| http://dx.doi.org/10.1001/jama.2024.3180 | DOI Listing |
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Comparative Effectiveness of Antivirals and Monoclonal Antibodies for Treating COVID-19 Patients Infected With Omicron Variant: A Systematic Review and Network Meta-Analysis.
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Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park, new Territories, Hong Kong SAR, China.
Antiviral drugs likely remain effective against the SARS-CoV-2 Omicron variant, while monoclonal antibody (mAb) therapies have experienced drops in neutralizing ability. This systematic review and network meta-analysis aims to estimate the comparative effectiveness of antivirals and mAb therapies for treating COVID-19 patients infected with Omicron, capturing primarily acute outcomes. We searched multiple databases from July 4 to July 19, 2022, with updates through November 4, 2022.
View Article and Find Full Text PDFMitigating unintentional injury deaths in sport and recreation: insights from 14 years of coroner recommendations in Québec, Canada.
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Direction de la sécurité dans le loisir et le sport, Ministère de l'Éducation du Québec, Trois-Rivières, Québec, Canada.
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Equitable and effective clinical guidance development and dissemination: trauma aims to lead the way.
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Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Thirty-four per cent of deaths among Americans aged 1-46 are due to injury, and many of these deaths could be prevented if all hospitals performed as well as the highest-performing hospitals. The Institute of Medicine and the National Academies of Science, Engineering and Medicine have called for learning health systems, with emphasis on clinical practice guidelines (CPGs) as a means of limiting preventable deaths. Reduction in mortality has been demonstrated when evidence-based trauma CPGs are adhered to; however, guidelines are variably updated, redundant, absent, inaccessible, or perceived as irrelevant.
View Article and Find Full Text PDFTranslation and psychometric validation of the Heart Failure Symptom Tracker (HFaST).
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NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisboa, Lisbon, Portugal.
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View Article and Find Full Text PDFRisk of mortality between warfarin and direct oral anticoagulants: population-based cohort studies.
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Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology & Population Health, London, School of Hygiene and Tropical Medicine, London, UK.
Background: Direct oral anticoagulants (DOACs) have been reported to be associated with a higher risk of mortality compared with an older alternative, warfarin using primary care data in the United Kingdom (UK). However, other studies observed contradictory findings. We therefore aimed to investigate the association between mortality and warfarin, compared with DOACs.
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