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Sequencing and Optical Genome Mapping for the Adventurous Chemist.
Chem Biomed Imaging
December 2024
Faculty of Science, Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, Flanders 3001, Belgium.
This review provides a comprehensive overview of the chemistries and workflows of the sequencing methods that have been or are currently commercially available, providing a very brief historical introduction to each method. The main optical genome mapping approaches are introduced in the same manner, although only a subset of these are or have ever been commercially available. The review comes with a deck of slides containing all of the figures for ease of access and consultation.
View Article and Find Full Text PDFThe Somogyi hypothesis: a parallelism with Michael Somogyi's life.
Hormones (Athens)
December 2024
Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Oviedo, Spain.
Michael Somogyi (Somogyi Mihály, 1883-1971) was a Hungarian biochemist who developed his scientific career in Europe and, primarily, the United States. He gave the name to the eponymous Somogyi effect or Somogyi hypothesis (in short, rebound hyperglycemia after insulin-induced hypoglycemia, particularly nocturnal), which was an axiom in the treatment of diabetes for decades. Although it is currently debated whether the Somogyi hypothesis is a real or relevant phenomenon in patients with diabetes, Somogyi's other significant career achievements are often overlooked.
View Article and Find Full Text PDFCrystal Chemistry and Design Principles of Altermagnets.
ACS Org Inorg Au
December 2024
Department of Materials Science & Engineering, University of Utah, Salt Lake City, Utah 84112, United States.
Altermagnetism was very recently identified as a new type of magnetic phase beyond the conventional dichotomy of ferromagnetism (FM) and antiferromagnetism (AFM). Its globally compensated magnetization and directional spin polarization promise new properties such as spin-polarized conductivity, spin-transfer torque, anomalous Hall effect, tunneling, and giant magnetoresistance that are highly useful for the next-generation memory devices, magnetic detectors, and energy conversion. Though this area has been historically led by the thin-film community, the identification of altermagnetism ultimately relies on precise magnetic structure determination, which can be most efficiently done in bulk materials.
View Article and Find Full Text PDFStirring the Pot: Antoine Baumé, Josiah Wedgwood, Pierre-Louis Guinand, and the Development of Optical Glass.
Ambix
November 2024
Independent Researcher, Briarcliff Manor, NY, USA.
The development of defect-free flint glass for use in telescopes and navigational instruments was a key technological challenge facing European chemists, natural philosophers, and artisans that emerged in the 1750s. In 1805, Pierre-Louis Guinand, a Swiss artisan, invented a fireclay stirrer used to stir molten flint glass to create a homogenous mixture relatively free of defects. In this paper, I show it was not Guinand, but French chemist Antoine Baumé, who first came up with the idea of using a fireclay stirrer.
View Article and Find Full Text PDFTribute to Kenneth Sauer (1931-2022): a mentor, a role-model, and an inspiration to all in the field of photosynthesis.
Photosynth Res
December 2024
Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.
Kenneth (Ken) Sauer was a mainstay of research in photosynthesis at the University of California, Berkeley and the Lawrence Berkeley National Laboratory (LBNL) for more than 50 years. Ken will be remembered by his colleagues, and other workers in the field of photosynthesis as well, for his pioneering work that introduced the physical techniques whose application have enriched our understanding of the basic reactions of oxygenic photosynthesis. His laboratory was a training ground for many students and postdocs who went on to success in the field of photosynthesis and many others.
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