In supermarkets and chemists worldwide, consumers are faced with an array of antimicrobial domestic cleaning and personal hygiene products purporting to kill germs and keep people safe. Many of these proven active ingredients (biocides) encourage the development of antimicrobial resistance (AMR) in microbes and microbial populations, in turn increasing the likelihood of AMR infections. In order to understand and address the selective pressure towards AMR posed by the unrestricted use of biocides, it is necessary to understand which biocides are most frequently found in consumer products and the current regulatory framework that governs their use. In this research we survey the biocidal active ingredients in the major categories of cleaning and personal care products available from supermarkets and pharmacies in Australia, and comment on the regulations that dictate how these products are tested and marketed. Benzalkonium chloride and ethanol were the two most prevalent antimicrobial biocides in this study, while triclosan, which is banned in several jurisdictions, was found in a small number of products. In Australia, many antimicrobial consumer products are regulated for efficacy and safety under the Therapeutic Goods Act, but the potential to drive microbial adaptation and AMR is not considered. Overall this survey underscores the broad use and light regulation of antimicrobial biocides in products available to the general public in Australia, and provides an information resource to inform further research and stewardship efforts.
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http://dx.doi.org/10.1099/acmi.0.000714.v3 | DOI Listing |
The ability to bring spatial resolution to omics studies enables a deeper understanding of cell populations and interactions in biological tissues. In the case of proteomics, single-cell and spatial approaches have been particularly challenging, due to limitations in sensitivity and throughput relative to other omics fields. Recent developments at the level of sample handling, chromatography, and mass spectrometry have set the stage for proteomics to be established in these new disciplines.
View Article and Find Full Text PDFEnviron Geochem Health
December 2024
School of Mechanical Engineering, Tongji University, Shanghai, 200092, China.
Environmental exposures to volatile organic compound (VOC) mixtures have received increasing attention, yet the risks are under studied. This study aimed to explore the risks of combined exposures to several commonly detected VOCs and to draw attention to the necessity of studying long-term and low-concentration environmental exposure patterns. In this study, we examined the effects of long-term and low-concentration exposures to VOCs like 1,2-dichlorobenzene, benzene, toluene and formaldehyde either alone or in combination on D.
View Article and Find Full Text PDFJ Am Assoc Lab Anim Sci
November 2024
1Research Animal Resources, University of Minnesota, Minneapolis, Minnesota.
Disinfectant application to gloved hands before handling SPF mice is standard practice to minimize transmission of pathogens and microbial contamination between cages. The risk of contamination with murine pathogens on gloves as well as the efficacy of disinfectant application for this step is largely unknown. This study aimed to determine if murine norovirus (MNV), Helicobacter spp.
View Article and Find Full Text PDFBMC Oral Health
December 2024
School of Dentistry, The University of Queensland, Brisbane, Australia.
Background: This randomized clinical trial aimed to evaluate the effect of intracanal cryotherapy with 2-4 °C normal saline irrigation on post-operative pain after single-visit non-surgical root canal retreatment.
Methods: Forty-six single-rooted, single-canal teeth requiring non-surgical root canal retreatment were randomly assigned to two groups (n = 23): a cryotherapy group and a control group. All the treatments were completed during a single visit.
BMC Oral Health
December 2024
Department of Pediatric Dentistry, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Background And Objectives: Although effective irrigation methods are crucial for pulpectomy in primary teeth (PT), no consensus exists on the best technique. This study guides clinicians in making evidence-based choices for irrigation techniques in PT.
Design: This study reviewed in vitro and in vivo research on PT using an extensive electronic search up to April 2024.
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