AI Article Synopsis
- Pancreatic cancer is highly resistant to treatment, making it difficult to manage effectively.
- The interaction between cancer cells and neutrophils leads to specific signaling that influences inflammation and immune response, which contributes to this resistance.
- By targeting the signaling pathway involved in these interactions, there's potential to improve the effectiveness of chemotherapy and immunotherapy for pancreatic cancer patients.
Article Abstract
Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer cell-neutrophil signaling circuitry provokes neutrophil-derived transmembrane (tm)TNF-TNFR2 interactions that dictate inflammatory polarization in cancer-associated fibroblasts and T-cell dysfunction - two hallmarks of therapeutic resistance. Targeting tmTNF-TNFR2 signaling may sensitize pancreatic cancer to chemo±immunotherapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936673 | PMC |
| http://dx.doi.org/10.1080/2162402X.2024.2326694 | DOI Listing |
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