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| http://dx.doi.org/10.1016/j.ekir.2024.01.046 | DOI Listing |
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A rationale for the poor response to alectinib in a patient with adenocarcinoma of the lung harbouring a fusion by artificial intelligence and molecular modelling: a case report.
Transl Lung Cancer Res
December 2024
Department of Physics and Center for Complexity and Biosystems, Università degli Studi di Milano and INFN, Milano, Italy.
Background: Non-small cell lung cancers (NSCLCs) with fusions are effectively treated with tyrosine kinase inhibitors (TKIs). The widespread use of next-generation sequencing (NGS) assays to study the molecular profile of NSCLCs, can identify rare fusion partners of . Therapy decisions are made without considering which fusion partner is present and its potential oncogenic properties.
View Article and Find Full Text PDFTracing the birth and intrinsic disorder of loops and domains in protein evolution.
Biophys Rev
December 2024
Evolutionary Bioinformatics Laboratory, Department of Crop Sciences and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
Protein loops and structural domains are building blocks of molecular structure. They hold evolutionary memory and are largely responsible for the many functions and processes that drive the living world. Here, we briefly review two decades of phylogenomic data-driven research focusing on the emergence and evolution of these elemental architects of protein structure.
View Article and Find Full Text PDFAcceptability and effectiveness of a study information video in improving the research consent process for youth: a non-inferiority trial.
BMJ Glob Health
January 2025
The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe.
Introduction: Obtaining informed consent for research includes the use of information sheets, which are often long and may be difficult for participants to understand. We conducted a trial to investigate whether consent procedures using a study information video coupled with electronic consent were non-inferior to standard consent procedures using participant information sheets (PIS) among youth aged 18-24 years in Zimbabwe.
Methods: The trial was nested within an endline population-based survey for a cluster-randomised trial from October 2021 to June 2022.
Surgical management of umbilical endometrioma within an umbilical hernia.
BMJ Case Rep
January 2025
Gynecology Oncology, Hackensack Meridian Jersey Shore University Medical Center, Neptune, New Jersey, USA
A nulliparous woman in her 40s is referred to gynaecological oncology secondary to umbilical pain and bleeding with menses. Examination revealed a blood-filled cystic mass within an umbilical hernia consistent with umbilical endometrioma. The patient exhausted medical management options, then pursued surgical management via umbilectomy, excision of umbilical endometriosis, lysis of adhesions and umbilical hernia repair.
View Article and Find Full Text PDFBackground: Contemporary methods of cardiovascular risk stratification are frequently inaccurate. Biomarkers such as high-sensitivity troponin I (hsTnI) have the potential to improve risk stratification. However, uncertainties exist regarding factors that determine hsTnI concentration.
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