Predictive value of preoperative platelet count and D-dimer levels for spinal cord injury following acute type a aortic dissection.

J Cardiothorac Surg

Cardiovascular surgery department, Fuwai Hospital, Chinese Academy of medicai sciences and Peking Union Medical College, National Center for Cardiovescular Diseases, Beijing, China.

Published: March 2024

AI Article Synopsis

  • This study investigates risk factors for spinal cord injury (SCI) in patients undergoing surgery for type A acute aortic dissection (TA-AAD).
  • The research was conducted on 481 patients who received a specific surgical treatment at Fuwai Hospital between September 2016 and April 2020.
  • The results showed that lower preoperative platelet counts and higher D-dimer levels are significant independent predictors of postoperative SCI in these patients, highlighting important clinical considerations for treatment.

Article Abstract

Background: This study aims to identify the risk factors contributing to spinal cord injury (SCI) following a type A acute aortic dissection (TA-AAD).

Methods: This retrospective study was conducted at a single center and involved 481 patients who received frozen elephant trunk stent implantation for TA-AAD. Additionally, these patients underwent total arch replacement with deep hypothermic circulatory arrest. This study was performed at Fuwai Hospital between September 2016 and April 2020.

Results: The resulting data of the multivariate logistic regression analysis demonstrated that preoperative platelet count (odds ratio [OR] = 0.774) and D-dimer levels (OR = 2.247) could serve as independent predictors for postoperative SCI in patients with TA-AAD.

Conclusion: The findings indicate that preoperative platelet count and D-dimer levels are independent risk factors for postoperative SCI in patients with TA-AAD. This study holds significant clinical implications regarding the prognosis and therapeutic responses for patients with TA-AAD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936092PMC
http://dx.doi.org/10.1186/s13019-024-02597-yDOI Listing

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