AI Article Synopsis
- Bacterial infections in wounds are a significant global health challenge, highlighting the need for effective treatments.
- This research introduces new methods for creating Metal-Alginate hydrogels using sodium alginate and various metal ions, producing a material useful for wound healing.
- Cu-Alginate, in particular, demonstrates strong antibacterial properties against multidrug-resistant bacteria while being low in toxicity and environmentally friendly, suggesting a promising advancement in wound care.
Article Abstract
Bacterial infections in wounds continue to be a major challenge in clinical settings worldwide and represent a significant threat to human health. This work proposes novel expandable and versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe, Co, Ni, Cu, and Zn) to create Metal-Alginate (M-Alg) hydrogel with adjustable morphology, composition, and microstructure. It conforms to the wound site, protects against second infection, reduces inflammation, and promotes the healing of infected wounds. Among these hydrogels, Cu-Alginate (Cu-Alg) shows excellent sterilization effect and good efficacy against both gram-positive and gram-negative bacteria, including multidrug-resistant (MDR) strains such as Methicillin-resistant Staphylococcus aureus (MRSA) and Carbapenem-resistant Klebsiella pneumoniae (CRKP) due to its dual antibacterial mechanisms: contact-killing and reactive oxygen species (ROS) burst. Importantly, it exhibits low cytotoxicity and biodegradability. This simple and cost-effective gel-based system has the potential to introduce an innovative approach to the management of wound infection and offers promising new perspectives for the advancement of wound care practice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/adhm.202303688 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioinspired Adhesive Hydrogel Platform with Photothermal Antimicrobial, Antioxidant, and Angiogenic Properties for Whole-Process Management of Diabetic Wounds.
ACS Appl Mater Interfaces
January 2025
Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou 646000, China.
Diabetic wound healing remains a major challenge in modern medicine. The persistent inflammation and immune dysfunction hinder angiogenesis by producing excessive ROS and increasing the susceptibility to bacterial infection. In this study, we developed an integrated strategy for whole-process management of diabetic wounds based on a bioinspired adhesive hydrogel platform with hemostasis, photothermal antimicrobial, antioxidant, anti-inflammatory, and angiogenic properties.
View Article and Find Full Text PDF[Sepsis caused by Pasteurella multocida after a dog bite].
Klin Mikrobiol Infekc Lek
March 2024
Infectious Department, Hospital Agel, Prostejov, Czech Repubic, e-mail:
This article reports a case of systemic infection caused by Pasteurella multocida. The infection was confirmed in a 79-year-old man who was admitted to the hospital after falling from a couch. The disease was manifested by the development of fever, chills, joint pain.
View Article and Find Full Text PDFA mouse coccygeal intervertebral disc degeneration model with tail-looping constructed using a suturing method.
Animal Model Exp Med
January 2025
Department of Orthopaedic Surgery, The 909th Hospital, School of Medicine, Xiamen University, Zhangzhou, China.
Backgroud: Intervertebral disc degeneration (IDD) is one of the common degenerative diseases. Due to ethical constraints, it is difficult to obtain sufficient research on humans, so the use of an animal model of IDD is very important to clarify the pathogenesis and treatment mechanism of the disease.
Methods: In this study, thirty 2-month-old mice were selected for operation to establish a coccygeal IDD model.
Effectiveness and safety of negative pressure wound therapy in patients with deep sternal wound infection: a systematic review and meta-analysis.
Int J Surg
December 2024
Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan and College of Medical, Chang Gung University, Taoyuan, Taiwan.
Background: Deep sternal wound infection (DSWI) is a severe and life-threatening complication following cardiovascular surgery. Negative pressure wound therapy (NPWT) has emerged as a promising therapeutic bridging option for DSWI. In this systematic review and meta-analysis, the authors aimed to evaluate the impact of NPWT on clinical outcomes in patients with DSWI.
View Article and Find Full Text PDFDeveloping a Risk Score for Predicting Multiple Revision Surgeries in Patients With Fracture-Related Infections.
J Am Acad Orthop Surg
January 2025
From the Department of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham, AL (Yeager, Rutz, Strother, Spitler, and Johnson), and the Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL (Gross, Benson, and Carter).
Introduction: Postoperative infections are a leading cause of morbidity following fracture repair. The purpose of this study is to develop a risk score predicting fracture-related infection (FRI) that will require one versus multiple revision surgeries related to infection eradication and bone healing.
Methods: This is a retrospective cohort study conducted at a single level I trauma center from 2013 to 2020.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!