AI Article Synopsis

  • - Recent research has identified a SARS-CoV-2-related virus, PCoV-GX/P2V, in pangolins, raising concerns about its potential to infect humans.
  • - PCoV-GX/P2V can effectively replicate in human cells and causes serious lung issues in mice, indicating its pathogenicity.
  • - Current immunity from SARS-CoV-2 may not protect against PCoV-GX/P2V, emphasizing the need for close monitoring to prevent cross-species transmission.

Article Abstract

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, PCoV-GX/P2V, which was isolated from a Malayan pangolin (Manis javanica). PCoV-GX/P2V could grow in human hepatoma, colorectal adenocarcinoma cells, and human primary nasal epithelial cells. It replicated more efficiently in cells expressing human angiotensin-converting enzyme 2 (hACE2) as SARS-CoV-2 did. After intranasal inoculation to the hACE2-transgenic mice, PCoV-GX/P2V not only replicated in nasal turbinate and lungs, but also caused interstitial pneumonia, characterized by infiltration of mixed inflammatory cells and multifocal alveolar hemorrhage. Existing population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V infection. These findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

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Source
http://dx.doi.org/10.1007/s11427-023-2484-xDOI Listing

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