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An analysis on role of iron deficiency in febrile seizure among children in 6 months to 5 years: A case-control study.
J Family Med Prim Care
December 2024
Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Tamil Nadu, India.
Background For The Study: This study looks into the relationship between febrile seizures in children between the ages of 6 months to 5 years who suffer from iron insufficiency. Febrile seizures, which are common in early life, are associated with abrupt temperature increases, and iron deficiency impacts neurological development in young infants. Understanding this relationship would lead to interventions that mitigate febrile seizure impact.
View Article and Find Full Text PDFCommon infections in children aged 6 months to 7 years after high prenatal exposure to perfluoroalkyl substances from contaminated drinking water in Ronneby, Sweden.
Environ Res
January 2025
Department of Laboratory Medicine, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden; Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Background: Perfluorinated alkyl substances (PFAS) are suggested to impair immune function in children. Previous studies investigating associations between prenatal PFAS exposure and common infections were performed in background-exposed populations whilst studies from high-exposed populations are lacking.
Objectives: To investigate the association between prenatal PFAS exposure from contaminated drinking water and common infections in children aged 6 months to 7 years in Ronneby, Sweden.
Impact analysis of infant antibiotic exposure on the burden of asthma: a simulation modeling study.
Front Allergy
December 2024
Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Infant antibiotic use is associated with increased risk of asthma. We examined the population impact of antibiotic exposure in the first year of life on the burden of pediatric asthma in British Columbia, Canada, using simulation modeling.
Methods: We performed a Bayesian meta-analysis of empirical studies to construct dose-response equations between antibiotic exposure in the first year of life and pediatric (<19 years of age) asthma.
Modulating cytokine microenvironment during T cell activation induces protective RSV-specific lung resident memory T cells in early life in mice.
Npj Viruses
December 2024
Department of Infectious Disease, Imperial College London, London, SW7 2AZ UK.
Maternal immunisation against respiratory viruses provides protection in early life, but as antibodies wane, there can be a gap in coverage. This immunity gap might be filled by inducing pathogen-specific lung tissue-resident T cells (TRM). However, the neonatal mouse lung has a different inflammatory environment to the adult lung which affects T cell recruitment.
View Article and Find Full Text PDFMechanistic modelling of allergen-induced airways disease in early life.
Sci Rep
January 2025
Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
Asthma affects approximately 300 million individuals worldwide and the onset predominantly arises in childhood. Children are exposed to multiple environmental irritants, such as viruses and allergens, that are common triggers for asthma onset, whilst their immune systems are developing in early life. Understanding the impact of allergen exposures on the developing immune system and resulting alterations in lung function in early life will help prevent the onset and progression of allergic asthma in children.
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