AI Article Synopsis

  • Salivary duct carcinoma (SDC) has a low 5-year survival rate of 40%, and the impact of brain metastasis (BM) on patient outcomes is not well understood.
  • A study of 464 SDC patients revealed that 14% had BM, with a median overall survival (mOS) of 13.1 months, and several factors linked to poorer survival, including performance status and uncontrolled disease.
  • A new prognostic tool, the SDC-graded prognostic assessment (GPA) score, shows varying mOS estimates based on different scores, demonstrating its effectiveness in estimating outcomes for patients with BM.

Article Abstract

Background: Salivary duct carcinoma (SDC) is a high-grade adenocarcinoma with a 5-year survival rate of 40%. Although drug therapy has improved patients' prognosis, the impact of brain metastasis (BM) remains poorly understood. We aimed to retrospectively examine the incidence of BM in patients with SDC (n = 464) and develop a tool to estimate their prognoses.

Methods: We retrospectively examined 464 patients with SDC enrolled in a multicenter study. We investigated the incidence of BM, overall survival (OS) rates, and factors affecting prognosis in patients with BM. We also developed an SDC-graded prognostic assessment (GPA) score for disease prognostication.

Results: Sixty-five (14%) patients had BM. The median OS (mOS) was 13.1 months. On univariate and multivariate analyses, factors such as Eastern Cooperative Oncology Group Performance Status >1, human epidermal growth factor receptor 2-negative status, and locoregional uncontrolled disease were associated with poor OS. SDC-GPA scores according to the prognostic factors were 0, 1, 2, and 3 points, and mOS estimates were 50.5, 16.1, 3.9, and 1.2 months, respectively (p < 0.001).

Conclusion: The SDC-GPA score emerged as a useful prognostication tool for patients with BM.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10935879PMC
http://dx.doi.org/10.1002/cam4.7037DOI Listing

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