Anti-Inflammatory Sesquiterpenes from Fruiting Bodies of .

, a fleshy fungus, is an important medicinal and food-homologous mushroom in China. In this work, eight undescribed sesquiterpenes schizomycins A-H (-) and one new meroterpenoid schizomycin I () together with three known analogues (-) were isolated from fruiting bodies of . Their planar structures were established by extensive spectroscopic and mass spectrometric data. The absolute configurations of compounds , , and were determined by single crystal X-ray diffraction, and compounds and - were confirmed by electronic circular dichroism calculations. Anti-inflammatory activities of all isolated compounds were evaluated for their inhibitory effects on IL-6 and IL-1β production in RAW 264.7 cells. Among them, compound exhibited significant IL-6 inhibitory activity with an IC value of 3.6 μM. The results of molecular docking showed that compound interacts with amino acid residues (Gly117, Lys118, Asp120, Thr166, and Try168) of the IL-6 receptor protein through hydrogen bonding.