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Epidemiology of tuberculosis among children in Beijing, China, 2012-2021. | LitMetric

Epidemiology of tuberculosis among children in Beijing, China, 2012-2021.

Epidemiol Infect

Laboratory of Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China.

Published: March 2024

AI Article Synopsis

  • A study at Beijing Children's Hospital examined TB cases among 3,193 children, finding that 51.05% had pulmonary TB (PTB) and 15.16% had extrapulmonary TB (EPTB), with TB meningitis being the most common form of EPTB.
  • Younger children aged 1-4 were more likely to have PTB and TB meningitis, whereas those aged 5-12 had a greater risk for EPTB, highlighting age-related trends in TB infections.
  • The proportion of PTB cases fluctuated over the years, rising from 40.9% in 2012 to 65% in 2019, before dropping to 17.8% in

Article Abstract

Data on epidemiology trends of paediatric tuberculosis (TB) are limited in China. So, we investigated the clinical and epidemiological profiles in diagnosed TB disease and TB infection patients at Beijing Children's Hospital. Of 3 193 patients, 51.05% had pulmonary TB (PTB) and 15.16% had extrapulmonary TB (EPTB). The most frequent forms of EPTB were TB meningitis (39.05%), pleural TB (29.75%), and disseminated TB (10.33%). PTB patients were significantly younger and associated with higher hospitalization frequency. Children aged 1-4 years exhibited higher risk of PTB and TB meningitis, and children aged 5-12 years had higher risk of EPTB. The proportion of PTB patients increased slightly from 40.9% in 2012 to 65% in 2019, and then decreased to 17.8% in 2021. The percentage of EPTB cases decreased from 18.3% in 2012 to 15.2% in 2019, but increased to 16.4% in 2021. Among EPTB cases, the largest increase was seen in TB meningitis. In conclusion, female and young children had higher risk of PTB in children. TB meningitis was the most frequent forms of EPTB among children, and young children were at high risk of TB meningitis. The distribution of different types of EPTB differed by age.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964184PMC
http://dx.doi.org/10.1017/S0950268824000414DOI Listing

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