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http://dx.doi.org/10.3389/fcvm.2024.1385809 | DOI Listing |
Front Pharmacol
December 2024
Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.
View Article and Find Full Text PDFFront Psychiatry
December 2024
Psychology Department, Arizona State University, Tempe, AZ, United States.
Introduction: Research has yet to examine the interplay between indices of environmental risk and resilience processes and genetic predisposition for epigenetic aging in predicting early adolescent depressive symptoms. In the current study we examine whether adverse life events and parental acceptance moderate polygenic predisposition for GrimAge epigenetic aging in predicting trajectories of depressive symptoms across early adolescence.
Method: Using data from the Adolescent Brain Development Study (ABCD, N = 11,875), we created polygenic scores for GrimAge, and examined whether exposure to adverse life events and parental acceptance moderated the relation between genetic risk and depressive symptom trajectories from age 10/11 to 12/13 using growth mixture modelling.
Front Cell Neurosci
December 2024
Istituto Italiano di Tecnologia, Synaptic Plasticity of Inhibitory Networks, Genova, Italy.
Front Sports Act Living
December 2024
Department of Sport Science, Human Performance Research Centre, University of Konstanz, Konstanz, Germany.
Background: The physical and mental demands of handball during training or competition often lead to fatigue which can impair performance. Many attempts have been made to assess the level of fatigue in athletes either by objective (neuromuscular performance) or subjective (questionnaires) measures, however, their interplay over short-, mid-, and long-term periods is currently unknown. Knowledge about both types of assessments is important as load management by coaches is traditionally based on direct adjustments following a training session, adjustments of content structure of training weeks between games, as well as adjustments of load management over the entire competitive season.
View Article and Find Full Text PDFAnn Coloproctol
December 2024
Department of Surgery, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Rectal cancer is one of the most common carcinomas and a leading cause of cancer-related mortality. Although significant advancements have been made in the treatment of rectal cancer, the deterioration of quality of life (QoL) remains a challenging issue. Various tools have been developed to assess QoL, including the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale, the QLQ-C30 and QLQ-CR29 by the European Organization for Research and Treatment of Cancer (EORTC), and the 36-Item Short Form Health Survey (SF-36).
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