The global increase in bacterial resistance poses a significant threat, jeopardizing the effectiveness of antibiotics. Therefore, the development of new and efficient antimicrobial agents is pre-dominant. Taking this into consideration, in the present study, we designed and reported the facile synthesis of two novel series benzothiazole-triazole and thiazolidinone-appended benzothiazole-triazole hybrids using a molecular hybridization approach in a one-pot process. The synthesized compounds were tested for microbial growth inhibition against bacterial and fungal strains. Among all the synthetics, compounds derived from methoxyphenyl and heteroaromatic ring substitutions exhibited promising inhibitory activity. The current investigation has emphasized that benzothiazole-triazole hybrids incorporating thiazolidinone can be a promising and potent category of molecules with potential biological activities. This sustainable and eco-friendly protocol involves the metal-free, catalyst-free synthesis of bioactive scaffolds, which merges broad tolerance for functional groups with a short reaction time, resulting in good to excellent yields.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10928519 | PMC |
| http://dx.doi.org/10.1039/d4ra00990h | DOI Listing |
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The global increase in bacterial resistance poses a significant threat, jeopardizing the effectiveness of antibiotics. Therefore, the development of new and efficient antimicrobial agents is pre-dominant. Taking this into consideration, in the present study, we designed and reported the facile synthesis of two novel series benzothiazole-triazole and thiazolidinone-appended benzothiazole-triazole hybrids using a molecular hybridization approach in a one-pot process.
View Article and Find Full Text PDFAn insight on medicinal attributes of 1,2,3- and 1,2,4-triazole derivatives as alpha-amylase and alpha-glucosidase inhibitors.
Mol Divers
October 2024
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India.
Article Synopsis
- Diabetes Mellitus (DM) is a widespread metabolic disorder characterized by high blood sugar levels due to insufficient insulin secretion, often caused by excessive glucose consumption.
- Enzymes like α-amylase and α-glucosidase are key players in carbohydrate metabolism, and targeting their inhibition represents a promising strategy for developing new antidiabetic medications.
- The review highlights various triazole-based compounds and their molecular hybrids that have shown potential in inhibiting the aforementioned enzymes, discussing their structure-activity relationships, enzyme inhibitory activities, and related patents to facilitate future therapeutic advancements.
Synthesis, in vitro and structural aspects of benzothiazole analogs as anti-oxidants and potential neuroprotective agents.
Environ Toxicol Pharmacol
October 2020
Functional Genomics and Disease Biology Laboratory, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, 613401, Tamil Nadu, India.
Catalase, an important antioxidant enzyme, is known to have a neuroprotective role against neurodegenerative disorder. Earlier study has focussed on benzothiazole-triazole hybrid molecules that are larger in size and molecular weight and inhibit the amyloid β (Aβ)-catalase interaction thus aid in neuroprotection. Here we have synthesized the novel benzothiazole molecules with low molecular weight using One-pot methodology and assayed the neuroprotective effects of the synthesized compounds in the U87 MG cell line under HO induced stressed condition and compared with other cell lines such as breast cancer (MCF-7) and macrophage (RAW-264.
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