Chronodisruption and Gut Microbiota: Triggering Glycemic Imbalance in People with Type 2 Diabetes.

Nutrients

Laboratorio de Biomedicina, Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico.

Published: February 2024

AI Article Synopsis

  • The desynchronization of physiological and behavioral processes affects gut microbiota and eating habits in mammals, linking it to the rise of conditions like Type 2 diabetes (T2D), obesity, and metabolic syndrome.
  • Recent findings suggest that resynchronizing these mechanisms could help control metabolic cycles and lower the risk of developing these chronic diseases.
  • The review discusses how imbalances in gut microbiota (eubiosis versus dysbiosis) make individuals more susceptible to chronic diseases and advocates for chronotherapy as a preventive approach.

Article Abstract

The desynchronization of physiological and behavioral mechanisms influences the gut microbiota and eating behavior in mammals, as shown in both rodents and humans, leading to the development of pathologies such as Type 2 diabetes (T2D), obesity, and metabolic syndrome. Recent studies propose resynchronization as a key input controlling metabolic cycles and contributing to reducing the risk of suffering some chronic diseases such as diabetes, obesity, or metabolic syndrome. In this analytical review, we present an overview of how desynchronization and its implications for the gut microbiome make people vulnerable to intestinal dysbiosis and consequent chronic diseases. In particular, we explore the eubiosis-dysbiosis phenomenon and, finally, propose some topics aimed at addressing chronotherapy as a key strategy in the prevention of chronic diseases.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10934040PMC
http://dx.doi.org/10.3390/nu16050616DOI Listing

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