Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds (IC = 0.07 μM) and (IC = 0.5 μM) showed significantly stronger inhibitory potency against -glucosidase than positive control acarbose. The study of the structure-activity relationship of these compounds provides a new clue for the development of new -glucosidase inhibitors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10935252 | PMC |
| http://dx.doi.org/10.3390/molecules29051179 | DOI Listing |
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Synthesis and Biological Evaluation of New Dihydrofuro[3,2-]piperidine Derivatives as Potent -Glucosidase Inhibitors.
Molecules
March 2024
Natural Products Research Centre, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds (IC = 0.
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