AI Article Synopsis
- A bacterium on human skin creates harmful toxins that can cause skin infections like atopic dermatitis, with these toxins transported in membrane vesicles (MVs) that provoke inflammation in host cells.* -
- A study tested the effects of two polyphenols, EGCG and NOL, finding that EGCG reduced the production of a specific toxin (Staphylococcal Enterotoxin A) and both compounds decreased biofilm formation and virulence-related gene expression.* -
- When the bacterium was grown with these polyphenols, the MVs had lower levels of toxins and led to reduced inflammation in human skin cells, indicating that EGCG and NOL could help manage skin inflammation.*
Article Abstract
, a bacterium found on human skin, produces toxins and various virulence factors that can lead to skin infections such as atopic dermatitis. These toxins and virulence factors are carried in membrane vesicles (MVs), composed of the bacterium's own cell membranes, and are expected to reach host target cells in a concentrated form, inducing inflammation. This study investigated the effects of two polyphenols, (-)-epigallocatechin gallate (EGCG) and nobiletin (NOL), on the expression of virulence factors and the inflammation induced by MVs. The study found that EGCG alone decreased the production of Staphylococcal Enterotoxin A (SEA), while both EGCG and NOL reduced biofilm formation and the expression of virulence factor-related genes. When was cultured in a broth supplemented with these polyphenols, the resulting MVs showed a reduction in SEA content and several cargo proteins. These MVs also exhibited decreased levels of inflammation-related gene expression in immortalized human keratinocytes. These results suggest that EGCG and NOL are expected to inhibit inflammation in the skin by altering the properties of MVs derived from .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10931263 | PMC |
| http://dx.doi.org/10.3390/cells13050387 | DOI Listing |
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