AI Article Synopsis
- * Knocking out the NbHAG1 gene increases susceptibility to CWMV, while overexpressing it enhances disease resistance, leading to the up-regulation of various resistance-related genes.
- * The study suggests that NbHAG1 helps activate these resistance genes by affecting the acetylation of histone H3 at a specific location (H3K36ac), making it a key player in plant defense mechanisms against viral threats.
Article Abstract
Post-translational modification of proteins plays a critical role in plant-pathogen interactions. Here, we demonstrate in that knockout of NbHAG1 promotes Chinese wheat mosaic virus (CWMV) infection, whereas NbHAG1 overexpression inhibits infection. Transcriptome sequencing indicated that a series of disease resistance-related genes were up-regulated after overexpression of NbHAG1. In addition, cleavage under targets and tagmentation (Cut&Tag)-qPCR results demonstrated that NbHAG1 may activate the transcription of its downstream disease-resistance genes by facilitating the acetylation level of H3K36ac. Therefore, we suggest that NbHAG1 is an important positive regulator of resistance to CWMV infestation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10931728 | PMC |
| http://dx.doi.org/10.3390/ijms25052800 | DOI Listing |
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