HIV Reservoirs and Treatment Strategies toward Curing HIV Infection.

Int J Mol Sci

Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima 890-8544, Japan.

Published: February 2024

Combination antiretroviral therapy (cART) has significantly improved the prognosis of individuals living with human immunodeficiency virus (HIV). Acquired immunodeficiency syndrome has transformed from a fatal disease to a treatable chronic infection. Currently, effective and safe anti-HIV drugs are available. Although cART can reduce viral production in the body of the patient to below the detection limit, it cannot eliminate the HIV provirus integrated into the host cell genome; hence, the virus will be produced again after cART discontinuation. Therefore, research into a cure (or remission) for HIV has been widely conducted. In this review, we focus on drug development targeting cells latently infected with HIV and assess the progress including our current studies, particularly in terms of the "Shock and Kill", and "Block and Lock" strategies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932120PMC
http://dx.doi.org/10.3390/ijms25052621DOI Listing

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