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The vocal fold vibrates in high frequency to create voice sound. The vocal fold has a sophisticated histological "layered structure" that enables such vibration. As the vibration causes fricative damage to the mucosa, excessive voicing can cause inflammation or injury to the mucosa. Chronic inflammation or repeated injury to the vocal fold occasionally induces scar formation in the mucosa, which can result in severe dysphonia, which is difficult to treat. Oxidative stress has been proven to be an important factor in aggravating the injury, which can lead to scarring. It is important to avoid excessive oxidative stress during the wound healing period. Excessive accumulation of reactive oxygen species (ROS) has been found in the injured vocal folds of rats during the early phase of wound healing. Antioxidants proved to be useful in preventing the accumulation of ROS during the period with less scar formation in the long-term results. Oxidative stress is also revealed to contribute to aging of the vocal fold, in which the mucosa becomes thin and stiff with a reduction in vibratory capacity. The aged voice can be characterized as weak and breathy. It has been confirmed that ROS gradually increases in rat vocal fold mucosa with age, which may cause further damage to the vocal fold. Antioxidants have also proved effective in avoiding aging of the vocal fold in rat models. Recently, human trials have shown significant effects of the antioxidant Twendee X for maintaining the voice of professional opera singers. In conclusion, it is suggested that oxidative stress has a great impact on the damage or deterioration of the vocal folds, and the use of antioxidants is effective for preventing damage of the vocal fold and maintaining the voice.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10932051 | PMC |
http://dx.doi.org/10.3390/ijms25052604 | DOI Listing |
J Voice
March 2025
Department of Otolaryngology, New York University Grossman School of Medicine, New York, NY. Electronic address:
Objectives/hypothesis: This study investigated the effects of the "crack-sob" onset-a distinctive vocal technique combining a sob gesture with an intentional pitch break-on vocal fold function during high-intensity singing. We hypothesized that this onset would either decrease glottal adduction and increase vocal fold vibration stability or alternatively, show no measurable effects while still providing perceived benefits to singers.
Study Design: Prospective observational cohort study.
J Clin Monit Comput
March 2025
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, 078-8510, Hokkaido, Japan.
The aim of this study was to compare the supramaximal currents obtained simultaneously by acceleromyography (AMG) TOF-Watch SX and electromyography (EMG) AF-201P in pediatric patients. Patients aged 2-11 years who underwent elective surgery under general anesthesia were enrolled. AMG and EMG monitors were placed on opposite arms of the patient to stimulate the ulnar nerve and monitor the adductor pollicis muscles following the induction of general anesthesia.
View Article and Find Full Text PDFWorld J Surg
March 2025
Department of Surgery, Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Introduction: The outcomes of completion thyroidectomy are not well-documented. The study aim is to compare the risks of total thyroidectomy (TT), thyroid lobectomy (TL), and completion thyroidectomy (CT) using a large multi-institutional database.
Methods: All cases of thyroidectomy without lymphadenectomy were identified using the CESQIP national database (2013-2023).
J Am Vet Med Assoc
March 2025
6Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Objective: To clinically and histopathologically characterize the laryngeal mass commonly referred to as vocal fold granuloma in brachycephalic dogs and to evaluate treatment responses and follow-up outcomes.
Animals: 13 brachycephalic dogs were included (8 French Bulldogs, 2 Bulldogs, 1 Pug, 1 Boston Terrier, and 1 Cavalier King Charles Spaniel).
Clinical Presentation: Brachycephalic dogs diagnosed with a vocal fold mass during endoscopic laryngeal examination were retrospectively included.
Ear Nose Throat J
March 2025
Department of Otolaryngology-Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, PA, USA.
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