AI Article Synopsis
- Palliative radiotherapy is an important treatment for symptom relief in women with various gynecological cancers, including cervical, endometrial, ovarian, vaginal, and vulvar cancers.
- A comprehensive review of literature revealed that while many studies focused on outcomes like symptom relief and quality of life, results were inconsistent and often limited by lack of standardized measures.
- Despite challenges in measuring overall effectiveness, the review found positive results for pain control and bleeding management, suggesting that further research is needed to optimize treatment regimens and improve patient outcomes.
Article Abstract
Background: Palliative radiotherapy plays a crucial role in managing symptomatic gynecological cancers (GCs). This article aims to systematically review literature studies on palliative pelvic radiotherapy in cervical, endometrial, ovarian, vaginal, and vulvar cancers. The primary focus is centered around evaluating symptom relief, quality of life (QOL), and toxicity in order to ascertain optimal radiotherapy regimens.
Methodology: For this thorough review, we mainly relied on Medline to gather papers published until November 2023. Selected studies specifically detailed symptomatology and QOL responses in palliative pelvic radiotherapy used for GCs.
Results: Thirty-one studies, mostly retrospective studies and those lacking standardized outcome measures, showed varied responses. Encouraging outcomes were noted in managing hemorrhage (55%) and pain control (70%). However, comprehensively assessing overall symptom response rates and toxicity remained challenging. Investigations into 10 Gy fractionation revealed benefits in addressing tumor-related bleeding and pain in female genital tract cancers.
Conclusions: Palliative pelvic radiotherapy effectively manages symptomatic GCs. Nonetheless, unresolved dosing and fractionation considerations warrant further investigation. Embracing modern therapies alongside radiotherapy offers improved symptom control, emphasizing the importance of selecting suitable patients for successful GC palliation interventions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10930860 | PMC |
| http://dx.doi.org/10.3390/diagnostics14050547 | DOI Listing |
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