AI Article Synopsis
- Long COVID diagnosis often depends on reported symptoms rather than biological evidence, which can lead to missed underlying conditions.
- A case study of a 26-year-old woman post-mild COVID-19 revealed persistent symptoms and discovered Bartonella henselae through clinical metagenomics.
- The study highlights the importance of using clinical metagenomics to diagnose hidden infections and suggests that bartonellosis should be considered in patients with unexplained lymph node swelling, even without known exposure to cats or fleas.
Article Abstract
The diagnosis of long COVID often relies on symptoms post-COVID-19, occasionally lacking biological evidence. This case study illustrates how investigating long COVID uncovered an underlying bartonellosis through clinical metagenomics. Following mild COVID-19, a 26-year-old woman experienced persistent symptoms during 5 months, including axillary adenopathy. Pathological examination, 16 S rRNA PCR, and clinical metagenomic analysis were done on an adenopathy biopsy. The latter revealed Bartonella henselae DNA and RNA. Treatment with clarithromycin improved symptoms. This case underscores the relevance of clinical metagenomics in diagnosing hidden infections. Post-COVID symptoms warrant thorough investigation, and bartonellosis should be considered in polyadenopathy cases, regardless of a recent history of cat or flea exposures.
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| http://dx.doi.org/10.1007/s10096-024-04801-2 | DOI Listing |
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