AI Article Synopsis
- Scientists have studied special channels in our body called TRP channels that help us feel pain for a long time.
- Even though early efforts to block one type called TRPV1 didn't work out, these channels are still seen as important for treating pain.
- Some treatments using capsaicin (a substance from peppers) are being tested to help with specific types of pain, like from arthritis and cancer.
Article Abstract
Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.
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| http://dx.doi.org/10.1016/j.coph.2024.102447 | DOI Listing |
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