AI Article Synopsis
- Multidrug-resistant tuberculosis (MDR-TB) patients who don't fully recover after treatment remain at risk of exposure to Minimum Inhibitory Concentration (MIC) and sub-MIC levels long after stopping drugs like bedaquiline (BDQ) or clofazimine (CFZ).
- Experiments show that cultures treated with sub-MIC levels of BDQ and CFZ led to an increase in mutant bacteria, indicating that these lower drug levels can select for pre-existing drug-resistant mutants.
- If these patients are not given another effective MDR-TB treatment, the potential for drug-resistant strains to thrive increases significantly.
Article Abstract
Multidrug-resistant tuberculosis (MDR-TB) patients not cured at the time of stopping treatment are exposed to Minimum Inhibitory Concentration (MIC) and sub-MIC levels for many months after discontinuing bedaquiline (BDQ) or clofazimine (CFZ) treatment. cultures treated with BDQ and CFZ sub-MIC concentrations clearly showed enrichment in the mutant population, demonstrating that pre-existing mutants can be selected by sub-MIC concentrations of BDQ and CFZ if not protected by an alternative MDR-TB treatment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10989023 | PMC |
| http://dx.doi.org/10.1128/aac.01275-23 | DOI Listing |
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