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Serum DLK1 During Minipuberty and Pubertal Transition in Healthy Girls and in Girls with Precocious Puberty.
J Clin Endocrinol Metab
October 2024
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen Denmark.
Article Synopsis
- DLK1, a protein linked to body weight, shows a decline in levels during infancy and through puberty in girls, with significant reductions noted in healthy infants.
- The study examined three groups: healthy infant girls, girls going through puberty, and those with central precocious puberty (CPP) undergoing treatment.
- Results indicate that DLK1 levels are not effective for diagnosing pubertal onset due to variability among individuals, but it does correlate negatively with birth weight and body fat percentage.
Postnatal Assessment of Minipuberty in Indian Preterm and Full-term Male Infants.
Indian Pediatr
March 2024
Department of Endocrinology, Gandhi Medical College and Hospital, Secunderabad, Telangana, India.
Objectives: To study the differences in the timing and magnitude of postnatal urinary gonadotropins and testosterone secretion during minipuberty in Indian preterm (PT) and full-term (FT) male infants.
Methods: This prospective observational study included 30 PT and 60 FT male infants. Urinary luteinizing hormone (LH), follicular stimulating hormone (FSH), and testosterone, and stretched penile length (SPL) and testicular volume (TV) were measured on day 7, first month, second month, fourth month and at six months of age.
Minipuberty in Full-term and Preterm Asian Indian Infants: The First Glance.
Indian Pediatr
March 2024
Professor and Head, Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India
Minipuberty in Male Full-term Neonates Appropriate and Small for Gestational Age and in Preterm Babies: Data from a Single Centre.
J Clin Res Pediatr Endocrinol
March 2024
University of Modena and Reggio Emilia, Department of Medical and Surgical Sciences of Mothers, Children and Adults, Paediatric Unit, Modena, Italy
Objective: The postnatal activation of the hypothalamic-pituitary-gonadal (HPG) axis is usually known as “minipuberty”. There are still open questions about its biological function and significance depending on sex, gestational age (GA) and birth weight (BW) with few available longitudinal data.
Methods: A single-centre, longitudinal study to quantify urinary follicle stimulating hormone (uFSH), luteinizing hormone (uLH) and testosterone (uTs) in male neonates.
The safety of neoadjuvant hormonal treatment in infants with cryptorchidism.
J Pediatr Urol
December 2022
Department of Urology, General University Hospital and 1st. Faculty of Medicine of Charles University in Prague, Czech Republic. Electronic address:
Background/purpose: The standard treatment for boys with non-syndromic cryptorchidism is an early orchidopexy. It is unclear if surgical intervention alone is enough for future fertility. Recent studies show benefit of neoadjuvant or adjuvant hormonal treatment with gonadorelin (GnRH) for spermatogonia maturation based on testicular biopsy.
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