Introduction: Alzheimer's disease (AD), the most common neurodegenerative disease, is characterized by accumulated amyloid-β (Aβ) plaques, aggregated phosphorylated tau protein, gliosis-associated neuroinflammation, synaptic dysfunction, and cognitive impairment. Many cohort studies indicate that tooth loss is a risk factor for AD. The detailed mechanisms underlying the association between AD and tooth loss, however, are not yet fully understood.
Methods: We explored the involvement of early tooth loss in the neuropathogenesis of the adult mouse AD model. The maxillary molars were extracted bilaterally in 1-month-old male mice soon after tooth eruption.
Results: Plasma corticosterone levels were increased and spatial learning memory was impaired in these mice at 6 months of age. The cerebral cortex and hippocampus of AD mice with extracted teeth showed an increased accumulation of Aβ plaques and phosphorylated tau proteins, and increased secretion of the proinflammatory cytokines, including interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α), accompanied by an increased number of microglia and astrocytes, and decreased synaptophysin expression. AD mice with extracted teeth also had a shorter lifespan than the control mice.
Discussion: These findings revealed that long-term tooth loss is a chronic stressor, activating the recruitment of microglia and astrocytes; exacerbating neuroinflammation, Aβ deposition, phosphorylated tau accumulation, and synaptic dysfunction; and leading to spatial learning and memory impairments in AD model mice.
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http://dx.doi.org/10.3389/fnagi.2024.1361847 | DOI Listing |
J Dent
December 2024
Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro (UFRJ). Rodolpho Paulo Rocco, 325, Rio de Janeiro, RJ, Brazil. ZIP Code: 21941-617. Electronic address:
Objectives: To identify and map the literature on the current state of pH-triggered strategies for resin-based materials used in direct restorative dentistry, focusing on innovative compounds, their incorporation and evaluation methods, and the main outcomes.
Data And Sources: Through a search across PubMed, Scopus, Embase, Web of Science, LILACS, Cochrane Library databases, and Google Scholar, this review identified studies pertinent to pH-responsive dental materials, excluding resin-modified glass ionomer cements.
Study Selection: From the 981 records identified, 19 in vitro studies were included, concentrating on resin-based composite resins (50%), dentin adhesives (25%), and sealants (25%).
Spec Care Dentist
December 2024
Department of Public Health, School of Health Sciences and Practice, New York Medical College, Valhalla, New York, USA.
Objective: Examining the association between oral health and the prevalence of falls among US caregivers.
Background: There is a scarcity of research on the association between oral health status and the prevalence of falls among older adults and caregivers.
Materials And Methods: Data from the Behavioral Risk Factor Surveillance System (BRFSS) surveys from 2016 to 2020 were analyzed.
J Clin Periodontol
December 2024
National Dental Research Institute Singapore, National Dental Centre Singapore, Singapore, Singapore.
Aim: To estimate the causal effects of smoking and cessation on tooth loss using instrumental variable (IV) analysis.
Material And Methods: Data from the Behavioural Risk Factor Surveillance System (BRFSS), conducted from 1995 to 2006, 2008, 2010, and 2012 in 50 U.S.
BMC Oral Health
December 2024
Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi, 329-0498, Japan.
Background: Tooth loss can lead to an increased risk of physical disease and a reduced quality of life. The current study investigated the association of the use of interdental cleaning devices with oral health outcomes such as tooth loss among employees as a healthier population.
Method: Tooth loss was determined as the main outcome in 2017 in a company employee population (n = 845, average age = 47.
BMC Oral Health
December 2024
Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, TX, 75246, USA.
Background: Oral diseases remain a significant public health problem worldwide, with growing gaps in oral health status among various socioeconomic groups. The objective of the current study is to analyze the impact of different social determinants of health (SDOH) on oral health outcomes (frequency of dental visits, self-reported oral health status, embarrassment because of oral health status, and tooth loss) among a representative sample of United States (U.S.
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