AI Article Synopsis
- - The study examined the durability of immunity following the third dose of COVID-19 vaccines in 94 healthy adults, finding that antibody levels remained significantly higher even 9-12 months later compared to levels after the second dose.
- - Anti-spike IgG antibody responses peaked after the third dose but gradually decreased over time; however, breakthrough infections during the Omicron period increased neutralizing antibodies against various strains.
- - The results suggest that the mRNA vaccine booster leads to lasting humoral immunity for at least a year and maintains T-cell immunity, indicating the potential for an annual COVID-19 vaccination approach.
Article Abstract
Background: Data on the durability of booster dose immunity of COVID-19 vaccines are relatively limited.
Methods: Immunogenicity was evaluated for up to 9-12 months after the third dose of vaccination in 94 healthy adults.
Results: Following the third dose, the anti-spike immunoglobulin G (IgG) antibody response against the wild-type was boosted markedly, which decreased gradually over time. However, even 9-12 months after the booster dose, both the median and geometric mean of anti-spike IgG antibody levels were higher than those measured 4 weeks after the second dose. Breakthrough infection during the Omicron-dominant period boosted neutralizing antibody titers against Omicron sublineages (BA.1 and BA.5) and the ancestral strain. T-cell immune response was efficiently induced and maintained during the study period.
Conclusions: mRNA vaccine booster dose elicited durable humoral immunity for up to 1 year after the third dose and T-cell immunity was sustained during the study period, supporting an annual COVID-19 vaccination strategy.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926122 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e27211 | DOI Listing |
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