AI Article Synopsis
- Mannosylerythritol-lipids-B (MEL-B) are glycolipids with benefits for skincare, including moisturizing and antimicrobial properties, which might be useful for treating acne-prone skin.
- A study aimed to evaluate the antimicrobial effect of MEL-B against certain bacteria using a broth macro dilution method, but the results showed that MEL-B did not inhibit the growth of C. acnes and may even support it.
- While MEL-B is recognized as beneficial for skincare, the findings suggest it should be avoided in formulations for acneic skin due to its lack of antimicrobial effects.
Article Abstract
Mannosylerythritol-lipids-B (MEL-B) are microbial-produced glycolipids with skincare properties, notably moisturizing, antimelanogenic, antimicrobial, and antiaging. Thus, there is a potential use of MEL-B in a formulation for treating acne-prone skin. This study investigated the antimicrobial effect of MEL-B against the Gram-positive bacteria . The broth macro dilution method was used to evaluate the growth of (3-4 CFU/mL), in the absence (positive control) or presence of MEL-B (128, 192, 256, and 512 μg/mL). Additionally, the leakage of genetic materials was used to determine the potential drug-induced membrane disruption of glycolipids. The amount of DNA and RNA release was quantified spectrophotometrically at 260 nm. Macro dilution technique and membrane integrity experiments showed that MEL-B does not have antimicrobial activity against C. acnes. Indeed, MEL-B assisted growth. Ultimately, MEL-B has been reported as a remarkably active compound for skincare formulations; however, preliminarily, it should be avoided for acneic skin.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924808 | PMC |
| http://dx.doi.org/10.1007/s12088-023-01169-3 | DOI Listing |
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