Correlation of Gut Microbiota with Children Obesity and Weight Loss.

Indian J Microbiol

Pathophysiology Department, Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, University of South China, Hengyang, 421001 Hunan People's Republic of China.

Published: March 2024

Unlabelled: Children obesity is a serious public health problem drawing much attention around the world. Recent research indicated that gut microbiota plays a vital role in children obesity, and disturbed gut microbiota is a prominent characteristic of obese children. Diet and exercise are efficient intervention for weight loss in obesity children, however, how the gut microbiota is modulated which remains largely unknown. To characterize the feature of gut microbiota in obese children and explore the effect of dietary and exercise on gut microbiota in simple obese children, 107 healthy children and 86 obese children were recruited, and among of the obese children 39 received the dietary-exercise combined weight loss intervention (DEI). The gut microbiota composition was detected by the 16S amplicon sequencing method. The gut microbiota composition was significantly different between obese children and the healthy cohort, and DEI significantly reduced the body weight and ameliorated the gut microbiota dysbiosis. After DEI, the abundance of the was increased, while the abundance of the genus was decreased in simple obese children. Our results may provide theoretical reference for future personalized obesity interventions based on gut microbiota.

Supplementary Information: The online version contains supplementary material available at 10.1007/s12088-023-01088-3.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924870PMC
http://dx.doi.org/10.1007/s12088-023-01088-3DOI Listing

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