Background: Tendinopathy refers to conditions characterized by collagen degeneration within tendon tissue, accompanied by the proliferation of capillaries and arteries, resulting in reduced mechanical function, pain, and swelling. While inflammation in tendinopathy can play a role in preventing infection, uncontrolled inflammation can hinder tissue regeneration and lead to fibrosis and impaired movement.
Objectives: The inability to regulate inflammation poses a significant limitation in tendinopathy treatment. Therefore, an ideal treatment strategy should involve modulation of the inflammatory process while promoting tissue regeneration.
Methods: The current review article was prepared by searching PubMed, Scopus, Web of Science, and Google Scholar databases. Several treatment approaches based on biomaterials have been developed.
Results: This review examines various treatment methods utilizing small molecules, biological compounds, herbal medicine-inspired approaches, immunotherapy, gene therapy, cell-based therapy, tissue engineering, nanotechnology, and phototherapy.
Conclusion: These treatments work through mechanisms of action involving signaling pathways such as transforming growth factor-beta (TGF-β), mitogen-activated protein kinases (MAPKs), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), all of which contribute to the repair of injured tendons.
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http://dx.doi.org/10.1111/fcp.12999 | DOI Listing |
J Nanobiotechnology
December 2024
GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avenida de la Ilustración, 18016, Granada, Spain.
MicroRNAs (miRNAs) have been recognised as potential biomarkers due to their specific expression patterns in different biological tissues and their changes in expression under pathological conditions. MicroRNA-122 (miR-122) is a vertebrate-specific miRNA that is predominantly expressed in the liver and plays an important role in liver metabolism and development. Dysregulation of miR-122 expression is associated with several liver-related diseases, including hepatocellular carcinoma and drug-induced liver injury (DILI).
View Article and Find Full Text PDFClin Teach
February 2025
Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Background: There remains a lack of diversity among those pursuing clinical academic careers. Structural inequalities, discrimination and a paucity of relatable role models can disadvantage minoritised students, hindering their educational experiences and career opportunities. Innovative and effective approaches are needed at an undergraduate level to address this problem, ensuring the pipeline is representative, diverse and inclusive.
View Article and Find Full Text PDFClin Teach
February 2025
Department of Internal Medicine, Division of General and Geriatric Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
Background: With increasing patient care responsibilities, administrative work and education demands, physicians may find it challenging to provide high-quality and engaging clinical education to third-year medical students on clerkships. Fourth-year students in the role of near-peer teachers can help fill this role, but they often also have competing responsibilities.
Approach: A 4-week Internal Medicine Student Chief (Student Chief) elective was created, designed such that fourth-year students would apply for dedicated time to serve as student leaders, coaches and educators for the third-year students on the Internal Medicine clerkship.
Phytochemistry
December 2024
College of Food Science and Technology, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address:
L., a member of the Oleaceae family with approximately 60 species worldwide, is widely distributed in the warm temperate zone of the northern hemisphere. It is not only used as a folk medicine for treating various illnesses but is also documented in medical books.
View Article and Find Full Text PDFSleep Med Rev
December 2024
Department of Psychology, University of North Texas, 1155 Union Circle, Denton, TX, 76203, USA.
Immigrants face unique challenges and stressors before leaving their country of origin and upon arrival to their host country, all of which may impair their sleep health. We synthesized the literature on pre-and-post migration factors predicting sleep outcomes among foreign-born Latin American immigrants to the United States. Following PRISMA guidelines, we searched three electronic databases: PubMed, PsycINFO, and Web of Science.
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