AI Article Synopsis
- PD-1 is a crucial receptor on T cells that helps regulate their activity, particularly in relation to immune responses.
- PD-L1 and PD-L2, the ligands for PD-1, are produced by different cells in the body and can change their expression levels in diseases like tumors and chronic inflammation.
- Recent advancements in immune checkpoint inhibitor therapies targeting PD-1 and PD-L1 have become effective treatments for various cancers, and this paper discusses the biological role of PD-1 and new molecular imaging technologies related to it.
Article Abstract
Programmed cell death-1 (PD-1) is one of the most famous coinhibitory receptors that are expressed on effector T cells to regulate their function. The PD-1 ligands, PD-L1 and PD-L2, are expressed by various cells throughout the body at steady state and their expression was further regulated within different pathological conditions such as tumor-bearing and chronic inflammatory diseases. In recent years, immune checkpoint inhibitor (ICI) therapies with anti-PD-1 or anti-PD-L1 has become a standard treatment for various malignancies and has shown remarkable antitumor effects. Since the discovery of PD-1 in 1992, a huge number of studies have been conducted to elucidate the function of PD-1. Herein, this paper provides an overview of PD-1 biological findings and sheds some light on the current technology for molecular imaging of PD-1.
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| http://dx.doi.org/10.1007/978-981-99-9781-7_13 | DOI Listing |
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