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The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC.
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Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Yonsei New ΙΙ Han Institute for Integrative Lung Cancer Research, Yonsei University of Medicine, Seoul, Republic of Korea. Electronic address:
Uncommon epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) pose therapeutic challenge due to limited response to EGFR tyrosine kinase inhibitors (TKIs). This study presents preclinical evidence and mechanistic insights into the combination of lazertinib, a third-generation EGFR-TKI; and amivantamab, an EGFR-MET bispecific antibody, for treating NSCLC with uncommon EGFR mutations. The lazertinib-amivantamab combination demonstrates significant antitumor activity in patient-derived models with uncommon EGFR mutations either before treatment or after progressing on EGFR-TKIs.
View Article and Find Full Text PDFOptimized design and experimental analysis of the vertical mixing plow for enhancing planosol improvement machine.
Sci Rep
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Intelligent Agricultural Machinery Equipment Engineering Laboratory, Harbin Cambridge University, Harbin, Heilongjiang, China.
Improved soil fertility to sustain crop productivity is important to enhance agroecosystem services. To address the low nutrient content, subsoil compaction, and poor root penetration in Planosol, a new machine was designed to improve these conditions. This machine integrates subsoil mixing and fertilizer application.
View Article and Find Full Text PDFCattle on the rocks: Understanding cattle mobility, diet, and seasonality in the Iberian Peninsula. The Middle Neolithic site of Cova de les Pixarelles (Tavertet, Osona).
PLoS One
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School of History Archaeology and Religion, Cardiff University, Cardiff, United Kingdom.
Reconstructing past herd mobility, reproduction, and diet is crucial for understanding animal management practices among the first sedentary farming communities. It can also shed light on how domestic animals were integrated into the existing exchange networks of goods, products, and raw materials, and how they contributed to broader economic and social changes during the Neolithic. Despite the longstanding importance of cattle (Bos taurus) to herders, the role of cattle in the daily, seasonal, and annual cycle of activities of early farming communities remains relatively poorly understood.
View Article and Find Full Text PDFMuscle contributions to propelling the body upward differ between skipping and running.
J Biomech
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Walker Department of Mechanical Engineering, The University of Texas at Austin Austin TX USA.
Skipping represents a training alternative to running due to its lower knee contact forces and higher whole-body metabolic cost. The increased metabolic cost of skipping is associated with a higher vertical center-of-mass (COM) displacement during the support and flight phases of the skipping hop compared to running. However, skipping has lower muscle force impulses than running.
View Article and Find Full Text PDFCost-effectiveness of integrated maternal HIV, syphilis, and hepatitis B screening opt-out strategies in Nepal: a modelling study.
Lancet Reg Health Southeast Asia
January 2025
Institute for Global Health, University College London, London, United Kingdom.
Background: The World Health Organisation (WHO) developed a comprehensive framework encouraging an integrated approach to achieve triple elimination of vertical transmission of HIV, syphilis, and hepatitis B in Asia. Current screening practices in Nepal show significantly lower coverage for syphilis and hepatitis B compared to HIV suggesting potential for integration. In this study, we aimed to model the cost-effectiveness of triple screening during antenatal care in Nepal.
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