An inside job: New roles for ApoE at the lipid droplet.

J Cell Biol

Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Published: April 2024

The secreted ApoE protein is a major regulator of lipid transport between brain cells. In this issue, Windham et al. (https://doi.org/10.1083/jcb.202305003) uncover a novel intracellular role for ApoE at the lipid droplet surface, where it regulates lipid droplet size and composition.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926614PMC
http://dx.doi.org/10.1083/jcb.202402171DOI Listing

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