AI Article Synopsis
- Uveal melanoma is the most common eye cancer in adults, known for its high rates of spreading and mortality.
- The study examined two types of PET/CT imaging—18 F-AlF-NOTA-PRGD2 and 18 F-FDG—used on a patient with primary uveal melanoma.
- Results showed that both imaging methods detected increased radioactive uptake in tumor lesions, with 18 F-AlF-NOTA-PRGD2 showing significantly higher uptake than 18 F-FDG.
Article Abstract
Uveal melanoma is the most common intraocular malignancy in adults with a high rate of metastasis and mortality. This study presented the PET/CT imaging of 18 F-AlF-NOTA-PRGD2 and 18 F-FDG in a patient with primary uveal melanoma. In addition to fundus photograph and ophthalmic ultrasonography, both 18 F-AlF-NOTA-PRGD2 and 18 F-FDG PET/CT imaging showed increased radioactive uptake in the lesions within the scan area. The tumoral lesions presented significantly higher uptake of 18 F-AlF-NOTA-PRGD2 compared with that of 18 F-FDG.
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Ultrasensitive detection of uveal melanoma using [F]AlF-NOTA-PRGD2 PET imaging.
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NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, Jiangsu Province, China.
Background: Uveal melanoma (UM) is the most common primary intraocular tumor in adults, and early detection is critical to improve the clinical outcome of this disease. In this study, the diagnostic effectiveness of [F]AlF-NOTA-PRGD2 (an investigational medicinal product) positron emission tomography (PET) imaging in UM xenografts and UM patients were evaluated. The cell uptake, cell binding ability and in vitro stability of [F]AlF-NOTA-PRGD2 were evaluated in 92-1 UM cell line.
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Article Synopsis
- Uveal melanoma is the most common eye cancer in adults, known for its high rates of spreading and mortality.
- The study examined two types of PET/CT imaging—18 F-AlF-NOTA-PRGD2 and 18 F-FDG—used on a patient with primary uveal melanoma.
- Results showed that both imaging methods detected increased radioactive uptake in tumor lesions, with 18 F-AlF-NOTA-PRGD2 showing significantly higher uptake than 18 F-FDG.
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aPET/CT of Imaging Department, Sichuan Cancer Hospital bNational Engineering Research Center for Biomaterials cDepartment of Radiology, West China Hospital, Sichuan University, Chengdu dThe Third People's Hospital of Chengdu, Chengdu eWuxi Molecular Imaging CRO Co. Ltd, Wuxi, People's Republic of China.
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