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Differentiating acute fatigue and overreaching during intensified training using a recursive least squares algorithm combined with the variable dose-response model.
Eur J Appl Physiol
December 2024
Club Des Dauphins de Guilherand-Granges, 07500, Guilherand-Granges, France.
Purpose: This study aimed to investigate whether the variable dose-response model, with estimates free to vary over time, can account for overreaching during intensified training in swimmers.
Methods: A time-varying model using a recursive least squares algorithm was applied to data from eight swimmers collected over 61 weeks, comprising five training cycles. Each data set included daily training load calculated from pool kilometers and dry land training equivalents, and performance measured twice weekly from 50 m trials.
DCSENets: Interpretable deep learning for patient-independent seizure classification using enhanced EEG-based spectrogram visualization.
Comput Biol Med
December 2024
School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China. Electronic address:
Neurologists often face challenges in identifying epileptic activities within multichannel EEG recordings, requiring extensive hours of analysis. Computer-aided diagnosis systems have been proposed to reduce manual inspection of EEG signals by neurologists. However, direct analysis of EEG signals is difficult due to their complex and dynamic nature, with variation across multiple patients.
View Article and Find Full Text PDFEvaluating the Effectiveness of mRNA-1273.815 Against COVID-19 Hospitalization Among Adults Aged ≥ 18 Years in the United States.
Infect Dis Ther
December 2024
Moderna, Inc., 325 Binney St., Cambridge, MA, 02142, USA.
Introduction: In September 2023 the Food and Drug Administration (FDA) approved an updated mRNA COVID-19 vaccine targeting the XBB.1.5 sublineage.
View Article and Find Full Text PDFAddressing treatment switching in the ALTA-1L trial with g-methods: exploring the impact of model specification.
BMC Med Res Methodol
December 2024
Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, Munich, Germany.
Article Synopsis
- Treatment switching in clinical trials complicates causal inference, making intention-to-treat (ITT) analyses less reliable for determining the true treatment effect.
- The ALTA-1L trial on brigatinib versus crizotinib highlighted this issue, showing more promising results for brigatinib when removed from treatment switching scenarios, via methods like Inverse Probability of Censoring Weights (IPCW).
- Re-analysis using IPCW and g-methods suggested that the treatment effect of brigatinib on overall survival may be significantly better than previously estimated, indicating that standard ITT analysis might underestimate treatment benefits.
Evaluation of the effects of fenestration in Fontan circulation using a lumped parameter model.
J Physiol Sci
December 2024
Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Fenestration has been reported to enhance Fontan hemodynamics in several cases of Fontan circulation. However, the indication criteria for fenestration remain under discussion. To assess the effectiveness of fenestration in Fontan circulation, we conducted a theoretical analysis using a computational model of the fenestrated Fontan circulation.
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