Targeted alpha therapy (TAT) is a promising form of oncology treatment utilising alpha-emitting radionuclides that can specifically accumulate at disease sites. The high energy and high linear energy transfer associated with alpha emissions causes localised damage at target sites whilst minimising that to surrounding healthy tissue. The lack of appropriate radionuclides has inhibited research in TAT. The identification of appropriate radionuclides should be primarily a function of the radionuclide's nuclear decay properties, and not their biochemistry or economic factors since these last two factors can change; however, the nuclear decay properties are fixed to that nuclide. This study has defined and applied a criterion based on nuclear decay properties useful for TAT. This down-selection exercise concluded that the most appropriate radionuclides are: 149 Tb, 211 At/ 211 Po, 212 Pb/ 212 Bi/ 212 Po, 213 Bi/ 213 Po, 224 Ra, 225 Ra/ 225 Ac/ 221 Fr, 226 Ac/ 226 Th, 227 Th/ 223 Ra/ 219 Rn, 229 U, 230 U/ 226 Th, and 253 Fm, the majority of which have previously been considered for TAT. 229 U and 253 Fm have been newly identified and could become new radionuclides of interest for TAT, depending on their decay chain progeny.
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http://dx.doi.org/10.1097/MNM.0000000000001832 | DOI Listing |
Eur J Nucl Med Mol Imaging
January 2025
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India.
Purpose: Enhancing therapeutic effectiveness is crucial for translating anticancer nanomedicines from laboratory to clinical settings. In this study, we have developed radioactive rhenium oxide nanoparticles encapsulated in human serum albumin ([Re]ReO-HSA NPs) for concurrent radiotherapy (RT) and photothermal therapy (PTT), aiming to optimize treatment outcomes.
Methods: [Re]ReO-HSA NPs were synthesized by a controlled reduction of ReO in HSA medium and extensively characterized.
Inorg Chem
January 2025
Department of Chemistry and Engineering Research Center of Advanced Rare-Earth Materials of Ministry of Education, Tsinghua University, Beijing 10084, China.
Actinide elements are characterized by their unique electronic correlations, variable valence states, and localized 5f electrons, leading to unconventional electronic and topological properties in their compounds. The distinctive physical properties of actinide materials are maintained in low-dimensional forms, yet two-dimensional (2D) actinide materials remain largely unexplored due to their scarcity and the experimental challenges posed by their radioactivity. To fill the knowledge gap in 2D actinide materials, we theoretically designed a series of stable thorium-containing 2D materials, including MXenes, chalcogenides, halides, and other compounds with unique structures.
View Article and Find Full Text PDFMar Pollut Bull
January 2025
School of Life Sciences, University of Essex, Colchester CO4 3SQ, UK.
Although oil and gas (O&G) derived produced waters and drill cuttings are known to contain enhanced levels of naturally occurring radium-228 (Ra) and radium-226 (Ra), most relevant ecological impact assessments have excluded radiological hazards and focus on other important contaminants, such as hydrocarbons and metals. Also, due to restricted access to the delimiting safety zone around operational O&G platforms, the few previous radioecological risk assessment studies have been conducted using seawater samples collected far from the main discharge point and applying default dilution and transfer factors to estimate concentrations of contaminants in biota. In this case study, sediment cores were collected close to a former O&G platform, Northwest Hutton (NWH), that used to be in the UK North Sea (61.
View Article and Find Full Text PDFPlant Cell Environ
January 2025
Research Center of Genetic Resources, National Agriculture and Food Research Organization, Ibaraki, Japan.
Vigna marina (Barm.) Merr. is adapted to tropical marine beaches and has an outstanding tolerance to salt stress.
View Article and Find Full Text PDFGels
January 2025
Nuclear Chemical Engineering Study Program, Polytechnic Institute of Nuclear Technology-BRIN, Yogyakarta 55281, Central Java, Indonesia.
Decommissioning of nuclear facilities can be performed in stages. One of the stages and processes in decontamination is the decontamination process before dismantling or facility area recovery activities. Decontamination can be performed using various methods, primarily physical and chemical.
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