Purpose: This paper describes previously unknown details about the discovery of resin adhesion to acid-etched human enamel.
Materials And Methods: A literature review was performed through manual assessments. Primary sources revealing the discovery of resin curing on etched enamel were analyzed considering the research objectives and methodological procedure during that era, including the type of teeth used, preparatory measures, acid-etching process, type of resin and its application, and follow-up observations. Additionally, the political and economic contexts were examined.
Results: In 1949, acid etching was found to promote adhesion with acrylic resin, a finding described again in 1955. The 1949 studies utilized nitric acid for enamel etching and the acrylate resin Paladon from the Kulzer company (Germany). Conversely, the 1955 investigations employed phosphoric acid and an unnamed acrylate, likely a self-curing resin supported by Kulzer in the late 1930s. Disparities in the 1949 and 1955 findings can be ascribed to varying objectives and test conditions amidst a turbulent political backdrop, significantly impacting the Kulzer company.
Conclusion: The discovery of resin adhesion to acid-etched enamel, approaching its 75th anniversary in 2024, is a landmark in 20th-century adhesive dentistry. Paladon represents a pioneering compound, exemplifying the influence of political, ideological, and economic factors on scientific advancements during that period.
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http://dx.doi.org/10.3290/j.jad.b5057135 | DOI Listing |
Sci Rep
January 2025
Department of Geoinformatics, Faculty of Science, Palacky University, 17. listopadu 50, 77146, Olomouc, Czech Republic.
The click beetles (Elateridae) represent the major and well-known group of the polyphagan superfamily Elateroidea. Despite a relatively rich fossil record of Mesozoic Elateridae, only a few species are described from the Upper Cretaceous Burmese amber. Although Elateridae spend most of their lives as larvae, our knowledge on immature stages of this family is limited, which is especially valid for the fossils.
View Article and Find Full Text PDFAnal Bioanal Chem
December 2024
Department of Physics and Astronomy, University of Calgary, 2500 University Dr. NW, Calgary, AB, T2N 1N4, Canada.
A fully automated dual-column purification procedure for Zn from biological samples, designed for subsequent Zn isotopic analysis, is presented that utilizes the prepFAST MC™ system (Elemental Scientific), DGA resin (TrisKem International), and TK201 resin (TrisKem International). The procedure developed enables the unattended processing of 20 samples per day and is characterized by low and reproduceable blanks (< 1.5 ng), no carry-over or memory effect, high reusability (> 50 times), high Zn yields 100.
View Article and Find Full Text PDFMol Cell Proteomics
December 2024
Biological Chemistry Department, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA; Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, 90095, USA; Molecular Biology Institute, UCLA, Los Angeles, CA, 90095, USA; DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, CA, 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, 90095, USA. Electronic address:
Cysteine chemoproteomic screening platforms are widely utilized for chemical probe and drug discovery campaigns. Chemoproteomic compound screens, which use a mass spectrometry-based proteomic readout, can interrogate the structure activity relationship (SAR) for thousands of proteins in parallel across the proteome. The versatility of chemoproteomic screens has been demonstrated across electrophilic, nucleophilic, and reversible classes of molecules.
View Article and Find Full Text PDFJ Pharm Biomed Anal
December 2024
Analytical Research & Development, Merck & Co., Inc., Boston, MA 02115, USA. Electronic address:
Biotherapeutics occupy a significant portion of the pharmaceutical pipeline and are projected to continue growing in sales and scope. Further, the field is advancing novel and more complex molecules beyond monoclonal antibodies including multi-target proteins, engineered proteins and bioconjugates. In this aspect, the development of increasingly advanced and challenging therapies necessitates a commiserate degree of innovation to develop automated methods for resin screening, purification, and analytics in the discovery space to quickly identify liabilities and rank candidates with minimal impact on developmental resources.
View Article and Find Full Text PDFThe first extinct Paleogene species of the Anobiinae genus Nicobium LeConte, 1861 is described based on an inclusion in Baltic amber. Two characteristic features distinguishing the extinct species (among other characters present in one combination or another in extant species) are sparse, inconspicuous elytral pubescence and rectangular, sharp posterior pronotal angles. The new species, Nicobium necrocrator sp.
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