Corrective shoe insoles are prescribed for a range of foot deformities and are typically designed based on a subjective assessment limiting personalization and potentially leading to sub optimal treatment outcomes. The incorporation of techniques in the design and customization of insoles may improve personalized correction and hence insole efficiency. We developed an workflow for insole design and customization using a combination of measured motion capture, inverse musculoskeletal modelling as well as forward simulation approaches to predict the kinematic response to specific insole designs. The developed workflow was tested on twenty-seven participants containing a combination of healthy participants (7) and patients with flatfoot deformity (20). Average error between measured and simulated kinematics were 4.7 ± 3.1, 4.5 ± 3.1, 2.3 ± 2.3, and 2.3 ± 2.7° for the chopart obliquity, chopart anterior-posterior axis, tarsometatarsal first ray, and tarsometatarsal fifth ray joints respectively. : The developed workflow offers distinct advantages to previous modeling workflows such as speed of use, use of more accessible data, use of only open-source software, and is highly automated. It provides a solid basis for future work on improving predictive accuracy by adapting the currently implemented insole model and incorporating additional data such as plantar pressure.
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http://dx.doi.org/10.3389/fbioe.2024.1351403 | DOI Listing |
Anal Bioanal Chem
January 2025
Doping Control Laboratory, Department of Diagnostic Sciences, Ghent University, Block B, Ottergemsesteenweg 460, BE-9000, Ghent, Belgium.
Dried urine spots have recently been proposed as an alternative matrix in the anti-doping field. Drying urine may open the opportunity to limit microbial and thermal degradation of the prohibited substances during transportation to the anti-doping laboratories without the need for refrigeration or freezing. In this study, a multi-targeted initial testing procedure was developed for the determination of 237 prohibited drugs/metabolites from 11 different classes in dried urine spots.
View Article and Find Full Text PDFSurg Endosc
January 2025
Surgery Department, Meander Medical Centre, Maatweg, Amersfoort, 3818 TZ, Utrecht, The Netherlands.
Background: Specific pelvic bone dimensions have been identified as predictors of total mesorectal excision (TME) difficulty and outcomes. However, manual measurement of these dimensions (pelvimetry) is labor intensive and thus, anatomic criteria are not included in the pre-operative difficulty assessment. In this work, we propose an automated workflow for pelvimetry based on pre-operative magnetic resonance imaging (MRI) volumes.
View Article and Find Full Text PDFEpilepsia
January 2025
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Objective: Somatic variants causing epilepsy are challenging to detect, as they are only present in a subset of brain cells (e.g., mosaic), resulting in low variant allele frequencies.
View Article and Find Full Text PDFGlia
January 2025
Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.
Neurological diseases are associated with disruptions in the brain lipidome that are becoming central to disease pathogenesis. Traditionally perceived as static structural support in membranes, lipids are now known to be actively involved in cellular signaling, energy metabolism, and other cellular activities involving membrane curvature, fluidity, fusion or fission. Glia are critical in the development, health, and function of the brain, and glial regulation plays a major role in disease.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Stanford University, Palo Alto, CA, USA.
Background: Genome-wide association studies (GWAS) have identified thousands of genomic regions associated with complex diseases but understanding the underlying causal mechanisms remains a significant challenge. The FunGen-xQTL project has addressed this by generating and harmonizing molecular quantitative trait loci (xQTL) across multiple layers of molecular traits in human brains, cerebrospinal fluid, and blood-derived cells relevant to neurodegenerative disorders. Existing approaches for integrating xQTL data with GWAS have typically focused on individual molecular traits in individual QTL layers.
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