Effective anti-tumor immunity is largely driven by cytotoxic CD8 T cells that can specifically recognize tumor antigens. However, the factors which ultimately dictate successful tumor rejection remain poorly understood. Here we identify a subpopulation of CD8 T cells which are tumor antigen-specific in patients with melanoma but resemble KIRCD8 T cells with a regulatory function (Tregs). These tumor antigen-specific KIRCD8 T cells are detectable in both the tumor and the blood, and higher levels of this population are associated with worse overall survival. Our findings therefore suggest that KIRCD8 Tregs are tumor antigen-specific but uniquely suppress anti-tumor immunity in patients with melanoma.
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| http://dx.doi.org/10.21203/rs.3.rs-3956671/v1 | DOI Listing |
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