AI Article Synopsis
- This paper presents an easy method to create a hydroxyapatite/chitosan (HAp/CS) composite scaffold with a 3D porous structure, without needing any chemical cross-linkers.
- The HAp particles have a unique urchin-like hollow design that boosts the scaffold's mechanical strength and biological activity.
- When tested on a rat bone defect model, the scaffold infused with periostin improved bone integration and regeneration, highlighting its potential for future bone repair applications.
Article Abstract
This paper reports a facile fabrication method of hydroxyapatite/chitosan (HAp/CS) composite scaffold with 3D porous structure without using any chemical cross-linkers. The HAp particles had an urchin-like hollow microstructure and high surface area, which was uniformly dispersed into the pore walls of the HAp/CS scaffold. The addition of HAp can efficiently enhance the mechanical properties and bioactivity of the HAp/CS scaffold. Moreover, periostin was successfully loaded onto the HAp/CS scaffold. When applied to the repair of bone defect in a rat mandibular model, the HAp/CS scaffold loaded with periostin can enhance osteointegration and accelerate bone regeneration. Our research combines periostin with the HAp/CS composite material, which provides a novel strategy to improve bone regeneration and has great application prospect in bone repair fields.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10920147 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e25832 | DOI Listing |
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