A series of novel ester derivatives of natural product geodin , isolated from the soft coral-derived fungus sp., were designed and semi-synthesised through one step reaction with high yield. Compound showed strong antifouling inhibitory activities ith MIC of 4.80 while compound showed selective inhibitory activities with MICs values 8.59 against and (Sea-Nine 211, MIC = 0.27 ). Compounds , and showed potent anti-pathogenic inhibitory activities with MICs of 2.29 4.29 and 4.56 respectively against (Ciprofloxacin, MIC = 0.156 M). Compound showed weak inhibitory activity against with MIC 18.75 (Sea-Nine 211, MIC = 0.27 ) and with MICs 9.38 against (ciprofloxacin, MIC = 0.156 ). However, compound showed very low antibacterial activities with MIC = >20 . The preliminary structure-activity relationships of compounds further prove that the modification of 4-OH group of natural product geodin improves the antibacterial activities such as antifouling and anti-pathogenic activities.
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