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Egg-induced adult food protein-induced enterocolitis syndrome: Clinical phenotypes, natural history and immunological characteristics.
J Allergy Clin Immunol Pract
June 2024
Allergy Service, Alicante General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain; Clinical Medicine Department, University Miguel Hernández, San Juan, Alicante, Spain.
Serum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis.
Parasit Vectors
May 2021
Institute of Hepatology, The Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang, People's Republic of China.
Background: Schistosoma japonicum is a parasitic flatworm that is the aetiological agent of human schistosomiasis, an important cause of hepatic fibrosis. Schistosomiasis-induced hepatic fibrosis is a consequence of the highly fibrogenic nature of egg-induced granulomatous lesions, which are the main pathogenic features of schistosomiasis. Although global awareness of the association between schistosomiasis-induced hepatic fibrosis and S.
View Article and Find Full Text PDFImmunopathology in schistosomiasis is regulated by TLR2,4- and IFN-γ-activated MSC through modulating Th1/Th2 responses.
Stem Cell Res Ther
June 2020
School of Medicine, South China University of Technology, Guangzhou, China.
Background And Aims: A marked egg-induced CD4 T cell programmed inflammation and subsequent hepatic fibrosis characterize the pathogenesis of schistosomiasis. Mesenchymal stem cell (MSC) has been extensively studied for the treatment of schistosomiasis. However, the mechanism by which MSCs modulate the pathogenesis of schistosomiasis has not been clarified.
View Article and Find Full Text PDFPlasma Endotoxin Levels Are Not Increased in -Infected Women without Signs or Symptoms of Hepatosplenic Disease.
Am J Trop Med Hyg
June 2020
Department of Medicine, Weill Cornell Medicine, New York, New York.
Elevated circulating endotoxin levels in the plasma of patients with advanced hepatosplenic schistosomiasis caused by have been reported, possibly caused by parasite egg-induced intestinal mucosal breaches facilitating bacterial access to the bloodstream. Neither endotoxin levels in people with but without hepatosplenic disease nor the impact of treatment on endotoxin levels have been described. We used a methodically optimized amebocyte lysate assay to measure plasma endotoxin in community-dwelling women from an endemic area without clinical hepatosplenic disease.
View Article and Find Full Text PDFChronic whipworm infection exacerbates Schistosoma mansoni egg-induced hepatopathology in non-human primates.
Parasit Vectors
February 2020
Center for Tropical Medicine and Infectious Diseases, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Background: Schistosomiasis continues to inflict significant morbidity and mortality in the tropical and subtropical regions of the world. The disease endemicity overlaps with the transmission of other parasitic diseases. Despite the ubiquity of polyparasitism in tropical regions, particularly in rural communities, little is known about the impact of multiple helminth infections on disease progression.
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