AI Article Synopsis
- Tranexamic acid (TXA) can significantly reduce mortality when used shortly after traumatic injuries due to its effects on bleeding control and other benefits.
- If administered after 3 hours post-injury, however, TXA may increase the risk of death from bleeding complications.
- While TXA is well-supported for reducing bleeding in isolated orthopedic surgeries, its safety and effectiveness for polytrauma patients outside the 3-hour window remain uncertain.
Article Abstract
Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely related to a combination of bleeding reduction and other non-bleeding effects. If TXA is given more than 3 h after traumatic injury, there is a significant and paradoxical increased risk of death due to bleeding. TXA has level 1 evidence for use as a bleeding reduction agent in isolated orthopedic operations, but in polytrauma patients undergoing orthopedic operations, it is not clear if and when TXA is safe or effective once outside the 3-h window of proven trauma efficacy.
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Source |
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| http://dx.doi.org/10.1111/trf.17779 | DOI Listing |
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