AI Article Synopsis
- SARS-CoV-2 variants of concern (VOCs), like Alpha from the UK, spread silently before being officially recognized, complicating timely interventions.
- Researchers analyzed the early spread of Alpha using various data sources, revealing that silent circulation could last from days to months and was influenced by the amount of genomic sequencing.
- The study highlights that implementing social restrictions in certain regions might have helped slow down local transmission, emphasizing the importance of proactive measures during emerging threats.
Article Abstract
SARS-CoV-2 variants of concern (VOCs) circulated cryptically before being identified as a threat, delaying interventions. Here we studied the drivers of such silent spread and its epidemic impact to inform future response planning. We focused on Alpha spread out of the UK. We integrated spatio-temporal records of international mobility, local epidemic growth and genomic surveillance into a Bayesian framework to reconstruct the first three months after Alpha emergence. We found that silent circulation lasted from days to months and decreased with the logarithm of sequencing coverage. Social restrictions in some countries likely delayed the establishment of local transmission, mitigating the negative consequences of late detection. Revisiting the initial spread of Alpha supports local mitigation at the destination in case of emerging events.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10925057 | PMC |
| http://dx.doi.org/10.1038/s41467-024-46345-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of water, sanitation, and hygiene indicators on enteric viral pathogens among under-5 children in low resource settings.
Sci Total Environ
January 2025
Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Poor water, sanitation, and hygiene (WASH) are the primary risks of exposure to enteric viral infection. Our study aimed to describe the role of WASH conditions and practices as risk factors for enteric viral infections in children under 5. Literature on the risk factors associated with all-cause diarrhea masks the taxa-specific drivers of diarrhea from specific pathogens, limiting the application of relevant control strategies.
View Article and Find Full Text PDFBusiness Venturing in Regulated Markets-Taxonomy and Archetypes of Digital Health Business Models in the European Union: Mixed Methods Descriptive and Exploratory Study.
J Med Internet Res
January 2025
Institute for Entrepreneurship, Technology Management and Innovation (EnTechnon), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Background: Digital health technology (DHT) has the potential to revolutionize the health care industry by reducing costs and improving the quality of care in a sector that faces significant challenges. However, the health care industry is complex, involving numerous stakeholders, and subject to extensive regulation. Within the European Union, medical device regulations impose stringent requirements on various ventures.
View Article and Find Full Text PDFA Qualitative Assessment of Barriers, Facilitators, and Outcomes in a Simulation-Based Collaborative Quality Improvement Program: The ImPACTS Project.
Pediatr Emerg Care
January 2025
Department of Emergency Medicine, Division of Pediatric Emergency Medicine, Mayo Clinic, Rochester, MN.
Objectives: ImPACTS (Improving Acute Care Through Simulation) is a collaborative simulation-based program partnering pediatric specialty centers ("hubs") with general emergency departments (GEDs) to improve pediatric acute care. Objective measurements of ImPACTS, such as evaluating Pediatric Readiness Score (PRS) and simulation-based outcome improvements, have been reported previously. Barriers to and facilitators of program involvement and the downstream effects of the program have not been previously described.
View Article and Find Full Text PDFResearch on the impact of the locations of luminaire failure on traffic safety in highway tunnels.
Traffic Inj Prev
January 2025
School of Civil and Transportation Engineering, Guangdong University of Technology, Guangzhou, China.
Objective: The safety of highway tunnels hinges heavily on proper lighting infrastructure, yet luminaire failures pose an ongoing challenge. The study aims at assessing the impact of the locations of luminaire failures on highway tunnels safety.
Methods: The research involved conducting 300 on-site scenarios with 29 participants, with simulated drives in visual recognition experiments.
Exploring evolution to uncover insights into protein mutational stability.
Mol Biol Evol
December 2024
Computational Biology and Bioinformatics, Université Libre de Bruxelles, 1050 Brussels, Belgium.
Determining the impact of mutations on the thermodynamic stability of proteins is essential for a wide range of applications such as rational protein design and genetic variant interpretation.Since protein stability is a major driver of evolution, evolutionary data are often used to guide stability predictions. Many state-of-the-art stability predictors extract evolutionary information from multiple sequence alignments (MSA) of proteins homologous to a query protein, and leverage it to predict the effects of mutations on protein stability.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!