AI Article Synopsis
- * There are currently no approved vaccines for Tularemia in the U.S., and existing traditional vaccination methods have safety and effectiveness issues.
- * The text highlights the need for innovative vaccine strategies and discusses current challenges in vaccine development against F. tularensis to enhance protection.
Article Abstract
Tularemia is caused by subspecies of Francisella tularensis and can manifest in a variety of disease states, with the pneumonic presentation resulting in the greatest mortality. Despite decades of research, there are no approved vaccines against F. tularensis in the United States. Traditional vaccination strategies, such as live-attenuated or subunit vaccines, are not favorable due to inadequate protection or safety concerns. Because of this, novel vaccination strategies are needed to combat tularemia. Here we discuss the current state of and challenges to the tularemia vaccine field and suggest novel vaccine approaches going forward that might be better suited for protecting against F. tularensis infection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095077 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2024.02.086 | DOI Listing |
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