AI Article Synopsis
- * Changes in signal transduction, cytokine production, and metabolism are significant in T cell dysfunction associated with SLE.
- * The review highlights how cAMP-dependent transcription factors, like CREB and CREM, affect immune responses by regulating important cytokine genes in CD4+ T cells, which may contribute to autoimmune issues in SLE.
Article Abstract
T lymphocytes play a major role in the pathophysiology of systemic lupus erythematosus. T cellular dysregulation includes significant alterations in signal transduction, cytokine production and metabolic pathways. The cAMP dependent transcription factors like CREB and CREM exert pleiotropic functions as they are critically involved in epigenetic conformational changes and gene regulation of different key effector cytokines in CD4+ T cells including that of IL2, IL17 and IL21 genes. In the present review we review current knowledge on altered expression and function of these factors in T cells that promote autoimmunity in SLE patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clim.2024.110179 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!