AI Article Synopsis
- Controlling too much inflammation can help reduce serious effects and deaths from the flu virus.
- RAGE is a factor involved in serious lung problems during severe flu infections, and researchers studied how to target it for treatment.
- The study found that using a RAGE blocker (FPS-ZM1) helped cells survive better and reduced sickness and death in mice infected with the flu.
Article Abstract
Controlling the excessive inflammatory response is one of the key ways to reduce the severity and mortality of severe influenza virus infections. RAGE is involved in inflammatory responses and acute lung injuries. Here, we investigated the role of RAGE and its potential application as a target for severe influenza treatment through serological correlation analysis for influenza patients, and treatment with the RAGE inhibitor FPS-ZM1 on A549 cells or mice with influenza A (H1N1) infection. The results showed high levels of RAGE were correlated with immunopathological injury and severity of influenza, and FPS-ZM1 treatment increased the viability of A549 cells with influenza A infection and decreased morbidity and mortality of influenza A virus infection in mice. The RAGE/NF-κb inflammatory signaling pathway is a major targeting pathway for FPS-ZM1 treatment in severe influenza. These findings provide further insights into the immune injury of severe influenza and a potential targeting candidate for the disease treatment.
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| http://dx.doi.org/10.1016/j.clim.2024.110178 | DOI Listing |
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